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公开(公告)号:US20100226923A1
公开(公告)日:2010-09-09
申请号:US12682864
申请日:2008-10-14
申请人: Ercole Rao , Vincent Mikol , Danxi Li , Jochen Kruip , Matthew Davison
发明人: Ercole Rao , Vincent Mikol , Danxi Li , Jochen Kruip , Matthew Davison
IPC分类号: A61K39/395 , C07K16/24 , A61P35/00 , A61P11/06 , A61P37/08
CPC分类号: C07K16/468 , C07K16/244 , C07K16/247 , C07K2317/31 , C07K2317/64 , C07K2317/76
摘要: The present invention relates to novel humanized anti-IL-4 and IL-13 antibodies and fragments thereof and novel bispecific antibodies and fragments thereof that specifically bind to IL-4 and IL-13. The invention also includes uses of the antibodies to treat or prevent IL-4 and/or IL-13 mediated diseases or disorders, including allergic asthma and dermatitis.
摘要翻译: 本发明涉及新型人源化抗IL-4和IL-13抗体及其片段以及特异性结合IL-4和IL-13的新型双特异性抗体及其片段。 本发明还包括抗体治疗或预防IL-4和/或IL-13介导的疾病或病症(包括过敏性哮喘和皮炎)的用途。
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公开(公告)号:US08388965B2
公开(公告)日:2013-03-05
申请号:US12682864
申请日:2008-10-14
申请人: Ercole Rao , Vincent Mikol , Danxi Li , Jochen Kruip , Matthew Davison
发明人: Ercole Rao , Vincent Mikol , Danxi Li , Jochen Kruip , Matthew Davison
IPC分类号: A61K39/395 , C07K16/24
CPC分类号: C07K16/468 , C07K16/244 , C07K16/247 , C07K2317/31 , C07K2317/64 , C07K2317/76
摘要: The present invention relates to novel humanized anti-IL-4 and IL-13 antibodies and fragments thereof and novel bispecific antibodies and fragments thereof that specifically bind to IL-4 and IL-13. The invention also includes uses of the antibodies to treat or prevent IL-4 and/or IL-13 mediated diseases or disorders, including allergic asthma and dermatitis.
摘要翻译: 本发明涉及新型人源化抗IL-4和IL-13抗体及其片段以及特异性结合IL-4和IL-13的新型双特异性抗体及其片段。 本发明还包括抗体治疗或预防IL-4和/或IL-13介导的疾病或病症(包括过敏性哮喘和皮炎)的用途。
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公开(公告)号:US07793267B2
公开(公告)日:2010-09-07
申请号:US11549410
申请日:2006-10-13
申请人: Matthew Davison , Mechelle Sophia Gittens , David Richard Godwin , Nazim H. Madhavji , Andriy Vladimir Miranskyy , Mark Francis Wilding
发明人: Matthew Davison , Mechelle Sophia Gittens , David Richard Godwin , Nazim H. Madhavji , Andriy Vladimir Miranskyy , Mark Francis Wilding
CPC分类号: G06F11/3476 , G06F11/3616 , G06F11/3636 , G06F11/3676
摘要: A computer implemented method, apparatus, and computer usable program code for performing software testing. A first set of traces is compressed to form a first set of compressed traces. The first set of compressed traces is compared to a plurality of additional traces to identify a set of partially matching traces within the plurality of additional traces. The first set of traces is compressed to form a second set of compressed traces. The second set of compressed traces is compressed according to a technique such that the second set of compressed traces contains more information than the first set of compressed traces. The second set of compressed traces is compared to the set of partially matching traces to identify a second set of partially matching traces within the set of partially matching traces. The second set of partially matching traces is placed in a memory.
摘要翻译: 用于执行软件测试的计算机实现的方法,装置和计算机可用程序代码。 第一组轨迹被压缩以形成第一组压缩轨迹。 将第一组压缩迹线与多个附加迹线进行比较,以识别多个附加迹线内的一组部分匹配的迹线。 第一组轨迹被压缩以形成第二组压缩轨迹。 第二组压缩迹线根据一种技术被压缩,使得第二组压缩迹线包含比第一组压缩迹线更多的信息。 将第二组压缩迹线与部分匹配迹线的集合进行比较,以识别部分匹配迹线集合内的第二组部分匹配迹线。 将第二组部分匹配的迹线放置在存储器中。
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公开(公告)号:US20080092123A1
公开(公告)日:2008-04-17
申请号:US11549410
申请日:2006-10-13
申请人: Matthew Davison , Mechelle Sophia Gittens , David Richard Godwin , Nazim H. Madhavji , Andriy Vladimir Miranskyy , Mark Francis Wilding
发明人: Matthew Davison , Mechelle Sophia Gittens , David Richard Godwin , Nazim H. Madhavji , Andriy Vladimir Miranskyy , Mark Francis Wilding
IPC分类号: G06F9/44
CPC分类号: G06F11/3476 , G06F11/3616 , G06F11/3636 , G06F11/3676
摘要: A computer implemented method, apparatus, and computer usable program code for performing software testing. A first set of traces is compressed to form a first set of compressed traces. The first set of compressed traces is compared to a plurality of additional traces to identify a set of partially matching traces within the plurality of additional traces. The first set of traces is compressed to form a second set of compressed traces. The second set of compressed traces is compressed according to a technique such that the second set of compressed traces contains more information than the first set of compressed traces. The second set of compressed traces is compared to the set of partially matching traces to identify a second set of partially matching traces within the set of partially matching traces. The second set of partially matching traces is placed in a memory.
摘要翻译: 用于执行软件测试的计算机实现的方法,装置和计算机可用程序代码。 第一组轨迹被压缩以形成第一组压缩轨迹。 将第一组压缩迹线与多个附加迹线进行比较,以识别多个附加迹线内的一组部分匹配的迹线。 第一组轨迹被压缩以形成第二组压缩轨迹。 第二组压缩迹线根据一种技术被压缩,使得第二组压缩迹线包含比第一组压缩迹线更多的信息。 将第二组压缩迹线与部分匹配迹线的集合进行比较,以识别部分匹配迹线集合内的第二组部分匹配迹线。 将第二组部分匹配的迹线放置在存储器中。
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