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公开(公告)号：US08933249B2
公开(公告)日：2015-01-13
申请号：US13534878
申请日：2012-06-27
申请人： Eric L. Stangeland , Priscilla Van Dyke , Timothy J. Church , Lori Jean Patterson , Daisuke Roland Saito
发明人： Eric L. Stangeland , Priscilla Van Dyke , Timothy J. Church , Lori Jean Patterson , Daisuke Roland Saito
IPC分类号： A61K31/40 , C07D207/08
CPC分类号： C07D207/08 , A61K31/40
摘要： In one aspect, the invention relates to compounds of formula I: where a and R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 一方面，本发明涉及式I化合物：其中a和R 1-6如说明书中所定义，或其药学上可接受的盐。 式I化合物是5-羟色胺和去甲肾上腺素再摄取抑制剂。 另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US07888386B2
公开(公告)日：2011-02-15
申请号：US12507965
申请日：2009-07-23
申请人： Eric L. Stangeland , Priscilla Van Dyke , Timothy J. Church , Lori Jean Patterson , Daisuke Roland Saito
发明人： Eric L. Stangeland , Priscilla Van Dyke , Timothy J. Church , Lori Jean Patterson , Daisuke Roland Saito
IPC分类号： A61K31/40 , C07D207/08
CPC分类号： C07D207/08 , A61K31/40
摘要： In one aspect, the invention relates to compounds of formula I: where a and R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 一方面，本发明涉及式I化合物：其中a和R 1-6如说明书中所定义，或其药学上可接受的盐。 式I化合物是5-羟色胺和去甲肾上腺素再摄取抑制剂。 另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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3.发明申请3-(PHENOXYPYRROLIDIN-3-YL-METHYL)HETEROARYL, 3-(PHENYLPYRROLIDIN-3-YLMETHOXY)HETEROARYL, AND 3-(HETEROARYLPYRROLIDIN-3-YLMETHOXY)HETEROARYL COMPOUNDS 审中-公开3-（苯基吡咯烷-3-基）甲基）异辛基，3-（苯基吡咯烷-3-基甲基）异烟肼和3-（异辛基吡咯烷-3-基甲氧基）杂环化合物公开(公告)号：US20100267743A1
公开(公告)日：2010-10-21
申请号：US12760276
申请日：2010-04-14
申请人： Eric L. Stangeland , Priscilla Van Dyke , Daisuke Roland Saito , Jane Schmidt , Lori Jean Patterson , Timothy J. Church , Adam Hughes
发明人： Eric L. Stangeland , Priscilla Van Dyke , Daisuke Roland Saito , Jane Schmidt , Lori Jean Patterson , Timothy J. Church , Adam Hughes
IPC分类号： A61K31/497 , C07D401/06 , A61K31/4439 , C07D277/28 , A61K31/427 , C07D403/06 , A61K31/506 , A61P25/28 , A61P25/24 , A61P25/08 , A61P25/16 , A61P3/04 , A61P25/02
CPC分类号： C07D401/06 , C07D207/08 , C07D401/12 , C07D403/06 , C07D405/06 , C07D413/06 , C07D417/06
摘要： In one aspect, the invention relates to compounds of formula I: where RA and RB are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 一方面，本发明涉及式I化合物：其中RA和RB如说明书中所定义，或其药学上可接受的盐。 式I化合物是5-羟色胺和去甲肾上腺素再摄取抑制剂。 另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US08242164B2
公开(公告)日：2012-08-14
申请号：US12984076
申请日：2011-01-04
申请人： Eric L. Stangeland , Priscilla Van Dyke , Timothy J. Church , Lori Jean Patterson , Daisuke Roland Saito
发明人： Eric L. Stangeland , Priscilla Van Dyke , Timothy J. Church , Lori Jean Patterson , Daisuke Roland Saito
CPC分类号： C07D207/08 , A61K31/40
摘要： In one aspect, the invention relates to compounds of formula I: where a and R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 一方面，本发明涉及式I化合物：其中a和R 1-6如说明书中所定义，或其药学上可接受的盐。 式I化合物是5-羟色胺和去甲肾上腺素再摄取抑制剂。 另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US20140243536A1
公开(公告)日：2014-08-28
申请号：US14090219
申请日：2013-11-26
IPC分类号： C07D207/08
CPC分类号： C07D207/08 , C07D207/12 , C07D401/12
摘要： In one aspect, the invention relates to compounds of formula I: where X, Y, R1, R2, R3, R4, R4, and n are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 一方面，本发明涉及式I的化合物：其中X，Y，R 1，R 2，R 3，R 4，R 4和n如说明书中所定义，或其药学上可接受的盐。 式I的化合物是5-羟色胺再摄取抑制剂。 另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US08471040B2
公开(公告)日：2013-06-25
申请号：US13269790
申请日：2011-10-10
IPC分类号： C07D207/04 , A61K31/40
CPC分类号： C07D207/08 , C07D207/12 , C07D401/12
摘要： In one aspect, the invention relates to compounds of formula I: where X, Y, R1, R2, R3, R4, R4, and n are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
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公开(公告)号：US20130237581A1
公开(公告)日：2013-09-12
申请号：US13870134
申请日：2013-04-25
申请人： Eric L. Stangeland , Jane Schmidt , Daisuke Roland Saito , Adam D. Hughes , Lori Jean Patterson
发明人： Eric L. Stangeland , Jane Schmidt , Daisuke Roland Saito , Adam D. Hughes , Lori Jean Patterson
IPC分类号： A61K31/40 , A61K31/4025
CPC分类号： A61K31/40 , A61K31/4025 , C07D207/08 , C07D405/06
摘要： In one aspect, the invention relates to compounds of formula I: where R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
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公开(公告)号：US08853255B2
公开(公告)日：2014-10-07
申请号：US13870134
申请日：2013-04-25
申请人： Eric L. Stangeland , Jane Schmidt , Daisuke Roland Saito , Adam D. Hughes , Lori Jean Patterson
发明人： Eric L. Stangeland , Jane Schmidt , Daisuke Roland Saito , Adam D. Hughes , Lori Jean Patterson
IPC分类号： A01N43/36 , A61K31/40 , C07D405/00 , C07D207/00 , C07D295/22 , C07D295/00
CPC分类号： A61K31/40 , A61K31/4025 , C07D207/08 , C07D405/06
摘要： In one aspect, the invention relates to compounds of formula I: where R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 一方面，本发明涉及式I的化合物：其中R1-6如说明书中所定义，或其药学上可接受的盐。 式I化合物是5-羟色胺和去甲肾上腺素再摄取抑制剂。 另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US08729119B2
公开(公告)日：2014-05-20
申请号：US13899841
申请日：2013-05-22
IPC分类号： A61K31/40 , C07D207/04
CPC分类号： C07D207/08 , C07D207/12 , C07D401/12
摘要： In one aspect, the invention relates to compounds of formula I: where X, Y, R1, R2, R3, R4, R4, and n are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 一方面，本发明涉及式I的化合物：其中X，Y，R 1，R 2，R 3，R 4，R 4和n如说明书中所定义，或其药学上可接受的盐。 式I的化合物是5-羟色胺再摄取抑制剂。 另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US09000191B2
公开(公告)日：2015-04-07
申请号：US14090219
申请日：2013-11-26
IPC分类号： C07D207/12 , C07D207/08 , C07D401/12
CPC分类号： C07D207/08 , C07D207/12 , C07D401/12
摘要： In one aspect, the invention relates to compounds of formula I: where X, Y, R1, R2, R3, R4, R4, and n are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 一方面，本发明涉及式I的化合物：其中X，Y，R 1，R 2，R 3，R 4，R 4和n如说明书中所定义，或其药学上可接受的盐。 式I的化合物是5-羟色胺再摄取抑制剂。 另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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