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公开(公告)号：US20060239918A1
公开(公告)日：2006-10-26
申请号：US11352383
申请日：2006-02-13
IPC分类号： A61B5/055
摘要： A method is disclosed for forecasting the contrast medium flow in a living body, in particular in a patient, in which a defined test bolus with a contrast medium is injected, preferably intravenously and with a known injection flow profile, into the body, preferably into a blood vessel. The time concentration profile of the contrast medium is observed and determined over a limited time period with a number of measuring instants at at least one location in the body with the aid of a tomographic method. The time profile of the contrast medium concentration of another contrast medium dose is forecast with the aid of a linear cause/effect formulation from the measured data obtained via the distribution of the contrast medium. The following calculation formula is then used for forecasting the time concentration profile {tilde over (c)}R(t) of the contrast medium at at least one of the previously measured locations of the body: c ~ R ( t ) = 1 F T ∑ n = na n = ne ∫ x = xa x = xe ⅆ t ′ c ~ R ( t + t 0 T - n Δ T - t ′ ) b R ′ ( t ′ ) .
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2.发明授权Method and system for providing tomographic pictures of a patient by using contrast medium injections 失效用于通过使用造影剂注射来提供患者的断层图像的方法和系统公开(公告)号：US07672711B2
公开(公告)日：2010-03-02
申请号：US11513182
申请日：2006-08-31
IPC分类号： A61B6/00
摘要： A method is disclosed for providing tomographic pictures of a patient with the aid of a tomographic system by using contrast medium injections. The patient is firstly injected with a defined test bolus, while the temporal concentration profile of the contrast medium in at least one body region is determined in at least one scanning plane. The functional parameters of a prediction model that maps or at least approximates the relationship between the profile of a contrast medium injection and the temporal profile of the contrast medium concentration in the body region are determined from the measured profile of the contrast medium concentration in relation to the profile of the test bolus injection. After the specification of a desired contrast in the body region, the profile of a contrast medium injection that is required therefore is automatically calculated in temporal relationship with the scan, and the start of the tomographic scan and the start of the contrast medium injection and the profile thereof are started automatically in a fashion temporally tuned to one another.
摘要翻译： 公开了一种通过使用造影剂注射来借助于断层摄影系统提供患者的断层图像的方法。 首先用限定的测试团注射患者，同时在至少一个扫描平面中确定造影剂在至少一个身体区域中的时间浓度分布。 根据造影剂浓度的测量轮廓确定对应于至少近似造影剂注射的轮廓与体区中的造影剂浓度的时间分布之间的关系的预测模型的功能参数， 测试推注的轮廓。 在身体区域中所需的对比度的指定之后，因此需要的造影剂注射的轮廓在与扫描的时间关系中自动计算，并且断层扫描的开始和造影剂注射的开始以及 其轮廓将以时间上相互调谐的方式自动启动。
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3.发明授权公开(公告)号：US08229547B2
公开(公告)日：2012-07-24
申请号：US12382959
申请日：2009-03-27
CPC分类号： A61B6/504 , A61B5/0402 , A61B6/032 , A61B6/481 , A61B6/507
摘要： A method is disclosed for determining and displaying perfusion parameters. In at least one embodiment, the method includes measuring an arterial contrast agent profile; measuring a contrast agent profile in a tissue of an organ; temporally synchronizing measured values of the arterial contrast agent profile and the contrast agent profile by interpolation; fitting a theoretical parameterized contrast agent profile to the measured contrast agent profile in the tissue by minimizing the differences between the theoretical and measured contrast agent profiles over a multiplicity of times in a measurement interval by fitting function parameters; and determining at least one perfusion parameter from the function parameters in the case of minimal deviation between the theoretical and measured contrast agent profiles.
摘要翻译： 公开了一种用于确定和显示灌注参数的方法。 在至少一个实施例中，该方法包括测量动脉造影剂特征; 测量器官组织中的造影剂特征; 通过插值时间同步动脉造影剂谱和造影剂图谱的测量值; 通过拟合功能参数，通过在测量间隔内在多次上最小化理论和测量的造影剂轮廓之间的差异，将理论参数化造影剂轮廓拟合到组织中测量的造影剂轮廓; 并且在理论和测量的造影剂概况之间的最小偏差的情况下，从功能参数确定至少一个灌注参数。
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4.发明申请公开(公告)号：US20090247864A1
公开(公告)日：2009-10-01
申请号：US12382959
申请日：2009-03-27
IPC分类号： A61B6/00
CPC分类号： A61B6/504 , A61B5/0402 , A61B6/032 , A61B6/481 , A61B6/507
摘要： A method is disclosed for determining and displaying perfusion parameters. In at least one embodiment, the method includes measuring an arterial contrast agent profile; measuring a contrast agent profile in a tissue of an organ; temporally synchronizing measured values of the arterial contrast agent profile and the contrast agent profile by interpolation; fitting a theoretical parametrized contrast agent profile to the measured contrast agent profile in the tissue by minimizing the differences between the theoretical and measured contrast agent profiles over a multiplicity of times in a measurement interval by fitting function parameters; and determining at least one perfusion parameter from the function parameters in the case of minimal deviation between the theoretical and measured contrast agent profiles.
摘要翻译： 公开了一种用于确定和显示灌注参数的方法。 在至少一个实施例中，该方法包括测量动脉造影剂特征; 测量器官组织中的造影剂特征; 通过插值时间同步动脉造影剂谱和造影剂图谱的测量值; 通过拟合功能参数，通过在测量间隔中最大限度地减少理论和测量的造影剂轮廓在测量间隔中的差异，将理论参数化造影剂轮廓拟合到组织中测量的造影剂轮廓; 并且在理论和测量的造影剂概况之间的最小偏差的情况下，从功能参数确定至少一个灌注参数。
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5.发明申请Method and system for providing tomographic pictures of a patient by using contrast medium injections 失效用于通过使用造影剂注射来提供患者的断层图像的方法和系统公开(公告)号：US20070066892A1
公开(公告)日：2007-03-22
申请号：US11513182
申请日：2006-08-31
IPC分类号： A61B5/05
摘要： A method is disclosed for providing tomographic pictures of a patient with the aid of a tomographic system by using contrast medium injections. The patient is firstly injected with a defined test bolus, while the temporal concentration profile of the contrast medium in at least one body region is determined in at least one scanning plane. The functional parameters of a prediction model that maps or at least approximates the relationship between the profile of a contrast medium injection and the temporal profile of the contrast medium concentration in the body region are determined from the measured profile of the contrast medium concentration in relation to the profile of the test bolus injection. After the specification of a desired contrast in the body region, the profile of a contrast medium injection that is required therefore is automatically calculated in temporal relationship with the scan, and the start of the tomographic scan and the start of the contrast medium injection and the profile thereof are started automatically in a fashion temporally tuned to one another.
摘要翻译： 公开了一种通过使用造影剂注射来借助于断层摄影系统提供患者的断层图像的方法。 首先用限定的测试团注射患者，同时在至少一个扫描平面中确定造影剂在至少一个身体区域中的时间浓度分布。 根据造影剂浓度的测量轮廓确定对应于至少近似造影剂注射的轮廓与体区中的造影剂浓度的时间分布之间的关系的预测模型的功能参数， 测试推注的轮廓。 在身体区域中所需的对比度的指定之后，因此需要的造影剂注射的轮廓在与扫描的时间关系中自动计算，并且断层扫描的开始和造影剂注射的开始以及 其轮廓将以时间上相互调谐的方式自动启动。
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