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公开(公告)号：US20100173883A1
公开(公告)日：2010-07-08
申请号：US12639708
申请日：2009-12-16
IPC分类号： A61K31/5685 , A61P9/10 , A61P25/28 , A61P25/02 , A61P25/16
CPC分类号： A61K31/5685
摘要： 3-Hydroxy-7β-hydroxy steroids and 3-oxo-7β-hydroxy steroids and pharmaceutically acceptable esters thereof are useful for protection against neuronal damage.
摘要翻译： 3-羟基-7β-羟基类固醇和3-氧代-7β-羟基类固醇及其药学上可接受的酯可用于保护免受神经损伤。
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公开(公告)号：US20100130459A1
公开(公告)日：2010-05-27
申请号：US12638529
申请日：2009-12-15
CPC分类号： A61K31/56
摘要： 3-Hydroxy-7β-hydroxy steroids and 3-oxo-7β-hydroxy steroids and pharmaceutically acceptable estors thereof are useful for protection against neuronal damage.
摘要翻译： 3-羟基-7β-羟基类固醇和3-氧代-7β-羟基类固醇及其药学上可接受的雌激素可用于保护免受神经元损伤。
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3.发明申请MODULATION OF PROSTAGLANDIN/CYCLOOXYGENASE METABOLIC PATHWAYS 审中-公开PROSTAGLANDIN / CYCLOOXYGENASE代谢途径的调节公开(公告)号：US20100137270A1
公开(公告)日：2010-06-03
申请号：US12516772
申请日：2007-11-29
申请人： Ernst Wülfert
发明人： Ernst Wülfert
IPC分类号： A61K31/566 , A61K31/568 , A61K31/4353 , A61K31/40 , C07D471/04 , C07D209/54 , C07D495/04 , C07D209/82 , C07J1/00 , A61K31/565 , A61K31/5685
CPC分类号： A61K31/568 , A61K31/566 , A61K31/5685
摘要： A variety of diseases and disorders associated with the metabolic pathways involved in the activities of cyclooxygenase and the synthesis of prostaglandins, for example type 2 diabetes mellitus and its sequelae, ischemic vascular diseases, pain associated with inflammation, inflammatory skin conditions, spinal cord injury, peripheral neuropathy, multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis, as well as various types of cancer may be treated or prevented by the use of an agent which selectively enhances production of 15-deoxy-prostaglandin J2.
摘要翻译： 与参与环氧合酶活性的代谢途径和前列腺素合成有关的各种疾病和病症，例如2型糖尿病及其后遗症，缺血性血管疾病，与炎症相关的疼痛，炎性皮肤病症，脊髓损伤， 周围神经病变，多发性硬化，炎症性肠病和类风湿性关节炎以及各种类型的癌症可以通过使用选择性地增强15-脱氧 - 前列腺素J2的生产的试剂来治疗或预防。
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