公开(公告)号：US12269920B2

公开(公告)日：2025-04-08

申请号：US17313506

申请日：2021-05-06

Applicant: Ethicon, Inc.

Inventor： Erman Senoz ,  Sasa Andjelic ,  Marc Brian Wisnudel

IPC: C08G63/78 ,  C08G63/08 ,  C08G63/64 ,  C08G63/82

Abstract: The present invention is directed to continuous reaction processes for preparing a glycolide/L-lactide copolymer formulation by continuously introducing glycolide monomer, L-lactide monomer, initiator and optionally a catalyst into at least one continuous reactor vessel under dry nitrogen environment, wherein the monomers, initiator, and optional catalyst are mixed at a first lower temperature and then transferred to a second continuous reactor operating at a second higher temperature, and then exothermally reacting and maintaining at a steady state, the blend of glycolide monomer, lactide monomer, initiator and optional catalyst to produce a PLGA copolymer reaction product.

公开(公告)号：US20210355273A1

公开(公告)日：2021-11-18

申请号：US17313506

申请日：2021-05-06

Applicant: Ethicon, Inc.

Inventor： Erman Senoz ,  Sasa Andjelic ,  Marc Brian Wisnudel

IPC: C08G63/78 ,  C08G63/64

Abstract: The present invention is directed to continuous reaction processes for preparing a glycolide/L-lactide copolymer formulation by continuously introducing glycolide monomer, L-lactide monomer, initiator and optionally a catalyst into at least one continuous reactor vessel under dry nitrogen environment, wherein the monomers, initiator, and optional catalyst are mixed at a first lower temperature and then transferred to a second continuous reactor operating at a second higher temperature, and then exothermally reacting and maintaining at a steady state, the blend of glycolide monomer, lactide monomer, initiator and optional catalyst to produce a PLGA copolymer reaction product.