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公开(公告)号:US20080214821A1
公开(公告)日:2008-09-04
申请号:US11917794
申请日:2005-11-28
申请人: Eun Sook Kim , Hee Cheol , Bo Sung Kwon , Sangmin Yun , Mi Young Ko , Cheol Kyung Kim , Kwee Hyun Suh
发明人: Eun Sook Kim , Hee Cheol , Bo Sung Kwon , Sangmin Yun , Mi Young Ko , Cheol Kyung Kim , Kwee Hyun Suh
IPC分类号: C07D495/04
CPC分类号: C07D495/04
摘要: Optically pure clopidogrel can be prepared in a high yield by optically resolving a racemic form of the compound of formula (II) using an optically active amine to form the optically active form of the compound of formula (III) or its acid-addition salt; and methylating the compound of formula (III) or its acid-addition salt.
摘要翻译: 光学纯氯吡格雷可以通过光学拆分式(II)化合物的外消旋形式,使用光学活性胺形成式(III)化合物或其酸加成盐的光学活性形式,以高产率制备; 并使式(III)化合物或其酸加成盐进行甲基化。