公开(公告)号：US11274157B2

公开(公告)日：2022-03-15

申请号：US16477509

申请日：2018-01-11

申请人： EUREKA THERAPEUTICS, INC.

发明人： Vivien Wai-Fan Chan ,  Hong Liu ,  Yoko Nakano ,  Yiyang Xu

IPC分类号： C07K16/28 ,  C07K14/725 ,  C07K14/705 ,  C07K16/46 ,  A61K47/68 ,  A61K35/17 ,  G01N33/569 ,  G01N33/574 ,  A61K39/00

摘要： The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising a histone H3 peptide and an MHC class I protein. Also provided are methods of making and using these constructs.

公开(公告)号：US20230048360A1

公开(公告)日：2023-02-16

申请号：US17817308

申请日：2022-08-03

申请人： Eureka Therapeutics, Inc.

发明人： Pengbo ZHANG ,  Yiyang Xu ,  Javier Morales ,  Yoko Nakano ,  Hong Liu ,  Jingyi Xiang ,  Timothy Acker

IPC分类号： C07K16/30 ,  A61P35/00 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  G01N33/574

摘要： The present application provides constructs comprising an antibody moiety specifically recognizing Glypican 3 (GPC3), such as a cell surface-bound GPC3. Also provided are methods of making and using these constructs.

公开(公告)号：US11447564B2

公开(公告)日：2022-09-20

申请号：US16608377

申请日：2018-04-24

申请人： EUREKA THERAPEUTICS, INC.

发明人： Pengbo Zhang ,  Yiyang Xu ,  Javier Morales ,  Yoko Nakano ,  Hong Liu ,  Jingyi Xiang ,  Timothy Acker

IPC分类号： C07K16/30 ,  A61P35/00 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  G01N33/574 ,  A61K39/00

摘要： The present application provides constructs comprising an antibody moiety specifically recognizing Glypican 3 (GPC3), such as a cell surface-bound GPC3. Also provided are methods of making and using these constructs.