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公开(公告)号：US20040081694A1
公开(公告)日：2004-04-29
申请号：US10690389
申请日：2003-10-21
申请人： Euro-Celtique, S.A.
发明人： Benjamin Oshlack , Mark Chasin , Hua-Pin Huang , David Sackler
IPC分类号： A61K009/26 , A61K031/485
CPC分类号： A61K9/1635 , A61K9/145 , A61K9/1617 , A61K9/1652 , A61K9/1694 , A61K9/2018 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2095 , B29B9/06 , Y10S514/951 , Y10S514/962
摘要： Bioavailable sustained release oral opioid analgesic dosage forms, comprising a plurality of multiparticulates produced via melt extrusion techniques are disclosed.
摘要翻译： 公开了包含通过熔融挤出技术生产的多个多颗粒的生物可用持续释放口服阿片类镇痛剂型。
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公开(公告)号：US20010036476A1
公开(公告)日：2001-11-01
申请号：US09777616
申请日：2001-02-06
申请人： Euro-Celtique S.A.
发明人： Benjamin Oshlack , Mark Chasin , Hua-Pin Huang , David Sackler
IPC分类号： A61K031/485 , A61K009/52 , A61K009/22
CPC分类号： A61K9/1635 , A61K9/145 , A61K9/1617 , A61K9/1652 , A61K9/1694 , A61K9/2018 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2095 , Y10S514/951 , Y10S514/962
摘要： Bioavailable sustained release oral opioid analgesic dosage forms, comprising a plurality of multiparticulates produced via melt extrusion techniques are disclosed.
摘要翻译： 公开了包含通过熔融挤出技术生产的多个多颗粒的生物可用持续释放口服阿片类镇痛剂型。
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公开(公告)号：US20040185096A1
公开(公告)日：2004-09-23
申请号：US10745950
申请日：2003-12-23
申请人： Euro-Celtique S.A.
发明人： Benjamin Oshlack , Mark Chasin , Hua-Pin Huang
IPC分类号： A61K009/22
CPC分类号： A61K9/1635 , A61K9/145 , A61K9/1617 , A61K9/1652 , A61K9/1694 , A61K9/2018 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2095 , Y10S514/951 , Y10S514/962
摘要： A unit dose sustained-release oral dosage form containing a plurality of melt-extruded particles, each consisting essentially of a therapeutically active agent, one or more retardants, and an optional water-insoluble binder is disclosed. The particles have a length of from about 0.1 to about 12 mm and can be of varying diameters and each unit dose provides a release of therapeutically active agents over at least about 8 hours. Methods of preparing the unit doses as well as extrusion processes and methods of treatment are also disclosed.
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公开(公告)号：US20040266807A1
公开(公告)日：2004-12-30
申请号：US10864829
申请日：2004-06-09
申请人： Euro-Celtique, S.A.
IPC分类号： A61K031/485 , A61K009/26
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/0087 , A61K9/1617 , A61K9/1635 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K9/2081 , A61K9/282 , A61K9/2846 , A61K9/4808 , A61K9/4866 , A61K9/50 , A61K9/5026
摘要： A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.
摘要翻译： 公开了一种固体口服缓释口服剂型的氢可酮。 包含镇痛有效量的氢可酮或其药学上可接受的盐的剂型和足够量的控制释放材料以使剂型适合于每天两次给予人类患者，所述剂型提供C12 / Cmax比为0.55至0.85，所述剂型提供至少约12小时的治疗效果。
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公开(公告)号：US20030026839A1
公开(公告)日：2003-02-06
申请号：US10038867
申请日：2002-01-02
申请人： Euro-Celtique S.A.
发明人： Benjamin Oshlack , Mark Chasin , Hua-Pin Huang
IPC分类号： A01N025/12 , A01N043/42 , A01N025/26 , A61K009/52 , A61K031/485
CPC分类号： A61K9/1635 , A61K9/145 , A61K9/1617 , A61K9/1652 , A61K9/1694 , A61K9/2018 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2095 , Y10S514/951 , Y10S514/962
摘要： A unit dose sustained-release oral dosage form containing a plurality of melt-extruded particles, each consisting essentially of a therapeutically active agent, one or more retardants, and an optional water-insoluble binder is disclosed. The particles have a length of from about 0.1 to about 12 mm and can be of varying diameters and each unit dose provides a release of therapeutically active agents over at least about 8 hours. Methods of preparing the unit doses as well as extrusion processes and methods of treatment are also disclosed.
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