公开(公告)号：US20100196396A1

公开(公告)日：2010-08-05

申请号：US12700009

申请日：2010-02-04

申请人： Eva Szentirmai ,  Levente Kapas ,  James M. Krueger

发明人： Eva Szentirmai ,  Levente Kapas ,  James M. Krueger

IPC分类号： A61K39/395 ,  A61K31/713 ,  A61K38/02 ,  A61P3/04 ,  A61P43/00

CPC分类号： A61K38/25 ,  A61K31/713 ,  C12N15/113 ,  C12N2310/14

摘要： In certain aspects, the preproghrelin gene, but not the ghrelin receptor (GHS-R1a) is required for normal integration of thermoregulation and sleep in mice. Particular aspects provide methods for modulation of thermoregulation and other ghrelin-mediated conditions (e.g., reduction of appetite or food intake, reduction of body weight or treatment of obesity, reduction of body temperature or induction of hypothermia, etc.), comprising administration of an inhibitor of ghrelin expression, and including, e.g., siRNA inhibition for treatment of obesity and for modulation of thermoregulation (e.g., induction of hypothermia in surgical settings benefiting from same). Additionally provided are methods for reducing body temperature or induction of hypothermia, comprising administration to a mammalian subject in need thereof an amount of an anti-obestatin antibody agent sufficient to reduce body temperature or induce hypothermia. Further methods comprise administration of a ghrelin peptide antagonist.

摘要翻译： 在某些方面，在小鼠体内正常的体温调节和睡眠整合需要预干扰素基因而不是生长素释放肽受体（GHS-R1a）。 特定方面提供调节温度调节和其他生长素释放肽介导的条件（例如减少食欲或食物摄入，减轻体重或治疗肥胖，降低体温或诱导低体温等）的方法，包括施用 并且包括例如用于治疗肥胖症和用于调节体温调节的siRNA抑制（例如，从受益于其的手术设置中诱导低体温）的抑制剂。 另外提供了用于降低体温或诱导低体温的方法，包括向有需要的哺乳动物受试者施用足量降低体温或诱发低体温的抗肥胖抑制素抗体剂量。 其它方法包括施用生长素释放肽肽拮抗剂。

公开(公告)号：US08309530B2

公开(公告)日：2012-11-13

申请号：US12700009

申请日：2010-02-04

申请人： Eva Szentirmai ,  Levente Kapas ,  James M. Krueger

发明人： Eva Szentirmai ,  Levente Kapas ,  James M. Krueger

IPC分类号： C12N15/11

CPC分类号： A61K38/25 ,  A61K31/713 ,  C12N15/113 ,  C12N2310/14

摘要： In certain aspects, the preproghrelin gene, but not the ghrelin receptor (GHS-R1a) is required for normal integration of thermoregulation and sleep in mice. Particular aspects provide methods for modulation of thermoregulation and other ghrelin-mediated conditions (e.g., reduction of appetite or food intake, reduction of body weight or treatment of obesity, reduction of body temperature or induction of hypothermia, etc.), comprising administration of an inhibitor of ghrelin expression, and including, e.g., siRNA inhibition for treatment of obesity and for modulation of thermoregulation (e.g., induction of hypothermia in surgical settings benefiting from same). Additionally provided are methods for reducing body temperature or induction of hypothermia, comprising administration to a mammalian subject in need thereof an amount of an anti-obestatin antibody agent sufficient to reduce body temperature or induce hypothermia. Further methods comprise administration of a ghrelin peptide antagonist.

摘要翻译： 在某些方面，在小鼠体内正常的体温调节和睡眠整合需要预干扰素基因而不是生长素释放肽受体（GHS-R1a）。 特定方面提供调节温度调节和其他生长素释放肽介导的条件（例如减少食欲或食物摄入，减轻体重或治疗肥胖，降低体温或诱导低体温等）的方法，包括施用 并且包括例如用于治疗肥胖症和用于调节体温调节的siRNA抑制（例如，从受益于其的手术设置中诱导低体温）的抑制剂。 另外提供了用于降低体温或诱导低体温的方法，包括向有需要的哺乳动物受试者施用足量降低体温或诱发低体温的抗肥胖抑制素抗体剂量。 其它方法包括施用生长素释放肽肽拮抗剂。