公开(公告)号：US08748108B2

公开(公告)日：2014-06-10

申请号：US13311752

申请日：2011-12-06

申请人： Evelyn M. McKeegan ,  Barry L. Dowell ,  Richard R. Lesniewski ,  Dimitrí Semizarov

发明人： Evelyn M. McKeegan ,  Barry L. Dowell ,  Richard R. Lesniewski ,  Dimitrí Semizarov

IPC分类号： G01N33/53 ,  A01N61/00

CPC分类号： G01N33/574 ,  G01N33/57484

摘要： Disclosed are methods for classifying a patient with cancer as a candidate for therapy with a Bcl-2 family inhibitor comprising determining the level of at least one biomarker in a sample and comparing the biomarker level to a threshold level. Also described are methods for identifying classes of patients having a refractory cancer for second-line therapy comprising a Bcl-2 family inhibitor, where the method comprises determining the level of at least one biomarker in a sample and comparing the biomarker level to a threshold level.

摘要翻译： 公开了用于将患有癌症的患者分类为用Bcl-2家族抑制剂治疗的候选物的方法，包括确定样品中至少一种生物标志物的水平并将生物标志物水平与阈值水平进行比较。 还描述了用于鉴定包含Bcl-2家族抑制剂的用于二线治疗的难治性癌症的患者类别的方法，其中所述方法包括测定样品中至少一种生物标志物的水平并将生物标志物水平与阈值水平进行比较 。