公开(公告)号：US10138524B2

公开(公告)日：2018-11-27

申请号：US15105178

申请日：2014-12-19

Applicant: Exact Sciences Development Company, LLC

Inventor： Ilse A. Tyler ,  Keith Yaeger ,  Michael J. Domanico ,  Hatim Allawi ,  Graham P. Lidgard

IPC: C12N15/11 ,  C12Q1/6886 ,  C12Q1/6876 ,  C12Q1/68

Abstract: The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic DNA strands of known composition for use as control molecules in stool DNA testing, e.g., of mutations and/or methylation of DNA isolated from stool samples.

公开(公告)号：US10889867B2

公开(公告)日：2021-01-12

申请号：US16168326

申请日：2018-10-23

Applicant: Exact Sciences Development Company, LLC

Inventor： Ilse A. Tyler ,  Keith Yaeger ,  Michael J. Domanico ,  Hatim Allawi ,  Graham P. Lidgard

IPC: C12Q1/68 ,  C12Q1/6886 ,  C12N15/11 ,  C12Q1/6876

Abstract: The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic DNA strands of known composition for use as control molecules in stool DNA testing, e.g., of mutations and/or methylation of DNA isolated from stool samples.

公开(公告)号：US20210172023A1

公开(公告)日：2021-06-10

申请号：US17110985

申请日：2020-12-03

Applicant: Exact Sciences Development Company, LLC

Inventor： Ilse A. Tyler ,  Keith Yaeger ,  Michael J. Domanico ,  Hatim Allawi ,  Graham P. Lidgard

IPC: C12Q1/6886 ,  C12N15/11 ,  C12Q1/6876

Abstract: The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic DNA strands of known composition for use as control molecules in stool DNA testing, e.g., of mutations and/or methylation of DNA isolated from stool samples.

公开(公告)号：US20190144948A1

公开(公告)日：2019-05-16

申请号：US16168326

申请日：2018-10-23

Applicant: Exact Sciences Development Company, LLC

Inventor： Ilse A. Tyler ,  Keith Yaeger ,  Michael J. Domanico ,  Hatim Allawi ,  Graham P. Lidgard

IPC: C12Q1/6886 ,  C12Q1/6876 ,  C12N15/11

Abstract: The present invention provides synthetic DNA strands that find use as controls or in nucleic acid testing methods. In particular, provided herein are synthetic DNA strands of known composition for use as control molecules in stool DNA testing, e.g., of mutations and/or methylation of DNA isolated from stool samples.