公开(公告)号：US20240347200A1

公开(公告)日：2024-10-17

申请号：US18636128

申请日：2024-04-15

申请人： Exai Bio, Inc.

发明人： Babak Alipanahi ,  Hani Goodarzi ,  Fereydoun Hormozdiari ,  Mehran Karimzadeh

IPC分类号： G16H50/20 ,  G06N3/0455 ,  G06N3/0895 ,  G16B40/20

CPC分类号： G16H50/20 ,  G06N3/0455 ,  G06N3/0895 ,  G16B40/20

摘要： Embodiments described herein provide a neural network based cancer detection and subtyping tool for predicting the presence of a tumor, its tissue of origin, and its subtype using small RNA sequencing (smRNA-seq) data, for example, the oncRNA count data. Specifically, the AI-based cancer detection and subtyping tool uses variational Bayes inference and semi-supervised training to adjust for batch effects and learn a low dimensional distribution explaining biological variability of the data. A method is also provided for determining the likely subtype(s) in a cancer sample.