公开(公告)号：US11124481B2

公开(公告)日：2021-09-21

申请号：US15500312

申请日：2015-07-31

Applicant: Exelixis, Inc.

Inventor： Wei Xu ,  David J. Donnelly ,  Patrick L. Chow ,  Benjamin J. Henley

IPC: C07D215/233 ,  C07D215/22

Abstract: The present invention relates to a method of preparing Cabozantinib (Cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinolin-4-yloxy)-phenylo]amide(4-fluoro-phenyl)amide) and 18F labeled Cabozantinib.

公开(公告)号：US20220194902A1

公开(公告)日：2022-06-23

申请号：US17466328

申请日：2021-09-03

Applicant: Exelixis, Inc.

Inventor： Wei Xu ,  David J. Donnelly ,  Patrick L. Chow ,  Benjamin J. Henley

IPC: C07D215/233 ,  C07D215/22

Abstract: The present invention relates to a method of preparing Cabozantinib (Cyclopropane-1,1-dicarboxylic acid [4-(6,7-di-methoxy-quinolin-4-vloxy)-phenyl]amide (4-fluoro-phenyl)amide) and 18F labeled Cabozantinib.

公开(公告)号：US20170217896A1

公开(公告)日：2017-08-03

申请号：US15500312

申请日：2015-07-31

Applicant: Exelixis, Inc.

Inventor： Wei XU ,  David J. Donnelly ,  Patrick L. Chow ,  Benjamin J. Henley

IPC: C07D215/233

CPC classification number: C07D215/233 ,  C07D215/22

Abstract: The present invention relates to a method of preparing Cabozantinib (Cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinolin-4-yloxy)-phenylo]amide(4-fluoro-phenyl)amide) and 18F labeled Cabozantinib.