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公开(公告)号：US11077132B2
公开(公告)日：2021-08-03
申请号：US15549021
申请日：2016-02-04
发明人： Richard E. Olson , Angela M. Cacace , Peter Hagedorn , Anja Mølhart Høg , Marianne Lerbech Jensen , Niels Fisker Nielsen , Dong Li , Jeffrey M. Brown , Stephen E. Mercer
IPC分类号： A61K31/712 , C12N15/113 , A61P25/28
摘要： The present invention relates to oligomer compounds (oligomers), which target Tau mRNA in a cell, leading to reduced expression of Tau protein. Reduction of Tau protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.
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公开(公告)号：US10799523B2
公开(公告)日：2020-10-13
申请号：US15016169
申请日：2016-02-04
发明人： Richard E. Olson , Angela M. Cacace , Peter Hagedorn , Anja Mølhart Høg , Dong Li , Jeffrey M. Brown , Marianne Lerbech Jensen , Niels Fisker Nielsen , Stephen E. Mercer
IPC分类号： A61K31/712 , C12N15/113 , A61P25/28
摘要： The present invention relates to oligomer compounds (oligomers), which target Tau mRNA in a cell, leading to reduced expression of Tau protein. Reduction of Tau protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.
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公开(公告)号：US20220143064A1
公开(公告)日：2022-05-12
申请号：US17367242
申请日：2021-07-02
发明人： Richard E. Olson , Angela M. Cacace , Peter Hagedorn , Anja Mølhart Høg , Marianne Lerbech Jensen , Niels Fisker Nielsen , Dong Li , Jeffrey M. Brown , Stephen E. Mercer
IPC分类号： A61K31/712 , C12N15/113 , A61P25/28
摘要： The present invention relates to oligomer compounds (oligomers), which target Tau mRNA in a cell, leading to reduced expression of Tau protein. Reduction of Tau protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.
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