公开(公告)号：US20240279312A1

公开(公告)日：2024-08-22

申请号：US18353623

申请日：2023-07-17

申请人： F. HOFFMANN-LA ROCHE AG

发明人： Elizabeth Booth ,  Virginia Montanini ,  John A. Hall ,  Jody Berry

IPC分类号： C07K14/745 ,  C07K14/705

CPC分类号： C07K14/745 ,  C07K14/705 ,  C07K2317/92 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/30

摘要： Composition comprising recombinant Gplbα receptor protein
Various aspects of the invention relate to recombinant polypeptides that specifically bind human von Willebrand Factor. Such recombinant polypeptides typically include a modified extracellular domain of platelet glycoprotein Ibα that typically comprises at least one mutation selected from G233T, D235V, and K237V, and such recombinant polypeptides optionally include an oligomerization domain.

公开(公告)号：US20230082465A1

公开(公告)日：2023-03-16

申请号：US17793483

申请日：2021-02-19

申请人： F. Hoffmann-La Roche AG

发明人： Elizabeth A. Booth ,  Charles Holz ,  Tristan Wasley ,  Virginia Montanini ,  Jody Berry

IPC分类号： C07K16/36

摘要： This application relates to anti-D-Dimer recombinant antibodies that specifically bind to fibrin and fibrinogen degradation products (FDP) such as D-Dimer, fragment DD and fragment D with high binding affinity and do not bind to fragment E and fibrinogen. The present invention also refers to methods and assays for detection of D-Dimer and FDP fragments in samples using said recombinant antibodies.