公开(公告)号：US20180230151A1

公开(公告)日：2018-08-16

申请号：US15429278

申请日：2017-02-10

Applicant: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.

Inventor： Marco Galvagni ,  Ennio Grendele ,  Giovanni Lora

IPC: C07D487/04 ,  A61K31/4985 ,  C12P7/26

CPC classification number: C07D487/04 ,  A61K31/4985 ,  C12P7/26

Abstract: An improved process for the preparation of Triazole and salts thereof, a key intermediate for the synthesis of Sitagliptine is disclosed.

公开(公告)号：US10047094B1

公开(公告)日：2018-08-14

申请号：US15429278

申请日：2017-02-10

Applicant: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.

Inventor： Marco Galvagni ,  Ennio Grendele ,  Giovanni Lora

IPC: C07D487/04 ,  A61K31/4985 ,  C12P7/26

Abstract: An improved process for the preparation of Triazole and salts thereof, a key intermediate for the synthesis of Sitagliptine is disclosed.

公开(公告)号：US09630944B2

公开(公告)日：2017-04-25

申请号：US14619542

申请日：2015-02-11

Applicant: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.

Inventor： Ennio Grendele ,  Alberto Soldà

IPC: C07D401/04

CPC classification number: C07D401/04

Abstract: The invention relates to an improved process for the preparation of Imatinib and salts thereof, in particular Imatinib Mesylate, having a content of a particular genotoxic impurity, named impurity F, within the pharmacopeia limits.