公开(公告)号：US20120207674A1

公开(公告)日：2012-08-16

申请号：US13028047

申请日：2011-02-15

Applicant: FATMA JASSAB FALEH MARZOOQ AL-SAEEDI

Inventor： FATMA JASSAB FALEH MARZOOQ AL-SAEEDI

IPC: A61K51/04 ,  C07F13/00

CPC classification number: A61K51/0406 ,  C07F13/005

Abstract: The cancer-imaging agent and method of radioimaging relates to the use of a radioimaging agent for the imaging increased choline uptake to detect cancerous tissue. The radioimaging agent includes choline or a pharmaceutically acceptable salt thereof labeled with technetium-99m. Preferably, the radioimaging agent is [methyl]-choline chloride labeled with 99mTcO4, which carries technetium-99m. In use, a patient is administered an effective amount of the radioimaging agent by injection and then scanned with a radioimaging device. The radioimaging agent is used to image select soft tissues in the patient, such as the liver or gallbladder, the upper abdominal organs, or the like, and to detect increased choline uptake. Choline is known to accumulate in cancerous cells. Thus, the radioimaging agent is particularly effective in the detection of potentially cancerous tissues.

Abstract translation: 癌症成像剂和放射成像方法涉及放射成像剂用于成像增加胆碱摄取以检测癌组织的用途。 放射成像剂包括用锝-99m标记的胆碱或其药学上可接受的盐。 优选地，放射成像剂是用99mTcO4标记的[甲基] - 胆碱氯化物，其携带锝-99m。 在使用中，患者通过注射施用有效量的放射成像剂，然后用放射成像装置进行扫描。 放射成像剂用于对患者中的软组织（例如肝或胆囊，上腹部器官等）成像，并检测胆碱摄取增加。 已知胆碱在癌细胞中积累。 因此，放射成像剂在潜在的癌组织的检测中特别有效。