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公开(公告)号:US20230056857A1
公开(公告)日:2023-02-23
申请号:US17976076
申请日:2022-10-28
发明人: Rosario Maria SANCHEZ MARTIN , Salvatore PERNAGALLO , Juan Diego UNCITI BROCETA , Luciano MESSINA , Susanna VACCARO , Laura PILOTTO
摘要: Disclosed is a nanoparticle system consisting of a polymer support or substrate in the form of nanoparticles to which a hydrolase enzyme able to degrade hyaluronic acid and one or more biologically and/or pharmacologically active molecules are covalently bonded, its preparation process and its uses in the diagnostic, prognostic and therapeutic fields.
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2.
公开(公告)号:US20180360990A1
公开(公告)日:2018-12-20
申请号:US16061220
申请日:2016-12-20
发明人: Rosario Maria SANCHEZ MARTIN , Salvatore PERNAGALLO , Juan Diego UNCITI BROCETA , Luciano MESSINA , Susanna VACCARO , Laura PILOTTO
摘要: Disclosed is a nanoparticle system consisting of a polymer support or substrate in the form of nanoparticles to which a hydrolase enzyme able to degrade hyaluronic acid and one or more biologically and/or pharmacologically active molecules are covalently bonded, its preparation process and its uses in the diagnostic, prognostic and therapeutic fields.
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