公开(公告)号：US20190210970A1

公开(公告)日：2019-07-11

申请号：US16235542

申请日：2018-12-28

Applicant: FORMA TM2, Inc.

Inventor： Jian Lin ,  Anna Ericsson ,  Ann-Marie Campbell ,  Gary Gustafson ,  Zhongguo Wang ,  R. Bruce Diebold ,  Susan Ashwell ,  David R. Lancia, JR. ,  Justin Andrew Caravella ,  Wei Lu

IPC: C07D215/227 ,  A61K31/4709 ,  C07D471/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

CPC classification number: C07D215/227 ,  A61K31/4709 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04

Abstract: The invention relates to methods of reducing the level of 2-hydroxyglutarate in cells by administration of an inhibitor of mutant isocitrate dehydrogenase-1.

公开(公告)号：US20190202790A1

公开(公告)日：2019-07-04

申请号：US16351457

申请日：2019-03-12

Applicant: FORMA TM2, Inc.

Inventor： Jian Lin ,  Anna Ericsson ,  Ann-Marie Campbell ,  Gary Gustafson ,  Zhongguo Wang ,  R. Bruce Diebold ,  Susan Ashwell ,  David R. Lancia, JR. ,  Justin Andrew Caravella ,  Wei Lu

IPC: C07D215/227 ,  C07D519/00 ,  A61P35/00 ,  C07D401/14 ,  C07D498/04 ,  C07D471/04 ,  C07D403/12 ,  C07D417/12 ,  C07D413/12 ,  C07D405/12 ,  C07D401/12 ,  C07D487/04

CPC classification number: C07D215/227 ,  A61P35/00 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D519/00

Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.

公开(公告)号：US20190210995A1

公开(公告)日：2019-07-11

申请号：US16235524

申请日：2018-12-28

Applicant: FORMA TM2, Inc.

Inventor： Jian Lin ,  Anna Ericsson ,  Ann-Marie Campbell ,  Gary Gustafson ,  Zhongguo Wang ,  R. Bruce Diebold ,  Susan Ashwell ,  David R. Lancia, JR. ,  Justin Andrew Caravella ,  Wei Lu

IPC: C07D401/12 ,  C07D403/12 ,  C07D409/14 ,  C07D471/04 ,  C07D405/14 ,  C07D417/14 ,  C07D401/14 ,  C07D413/14

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: The invention relates to methods of reducing the level of 2-hydroxyglutarate in cells by administration of an inhibitor of mutant isocitrate dehydrogenase-1.