Patent search ap:("FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE") AND inv:"Minako HOSHI" Page 1

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发明申请
CROSS-LINKED PRODUCT OF AMYLOID-B PROTEIN (AB) AS POTENTIAL SUBSTITUTE FOR AMYLOSPHEROIDS (ASPD) AND ANALYSIS OF ASPD 有权

公开(公告)号：US20230021187A1

公开(公告)日：2023-01-19

申请号：US17777846

申请日：2020-11-18

Applicant: FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE

Inventor： Minako HOSHI , Yoshie ARAI , Kiyotaka MACHIDA

IPC: C07K14/47 , G01N33/531 , G01N33/68 , G01N33/547

Abstract: A substance that can be a substitute for amylospheroids (ASPD) and a method for analyzing ASPD are provided. Viewed from one aspect, the present disclosure relates to a substance in which amyloid-β protein (Aβ) is cross-linked with a cross-linking agent that has a spacer arm length of between 4 Å and 50 Å inclusive or a cross-linking agent that has, as a spacer arm, not less than 1 and not more than 13 groups that are an oxyethylene group(s) (—CH2CH2O—) and/or an oxypropylene group(s) (—CH2CH2CH3O—). Viewed from another aspect, the present disclosure relates to a method for analyzing ASPD using the substance as a reference material.

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