公开(公告)号：US20220160832A1

公开(公告)日：2022-05-26

申请号：US17643410

申请日：2021-12-08

申请人： FRED HUTCHINSON CANCER RESEARCH CENTER

发明人： Rachel PERRET ,  Philip D. GREENBERG ,  Thomas M. SCHMITT ,  Aude G. CHAPUIS ,  Ingunn M. STROMNES ,  Tijana MARTINOV

IPC分类号： A61K38/17 ,  A61P35/00 ,  A61K35/17

摘要： The present disclosure provides compositions and methods for targeting a Ras antigen to, for example, treat or prevent cancer. Disclosed embodiments include binding proteins, such as a T cell receptor or a chimeric antigen receptor, that bind to a Ras antigen:HLA complex. Polynucleotides encoding such binding protein can introduced into a host cell, such as a T cell, and the cell can be used in immunotherapy for treating various cancers. Also provided are immunogenic polypeptides that can be useful to, for example, induce an immune response against a mutated Ras or to identify a binding protein that binds to a Ras antigen.

公开(公告)号：US20210379150A1

公开(公告)日：2021-12-09

申请号：US17408340

申请日：2021-08-20

申请人： FRED HUTCHINSON CANCER RESEARCH CENTER

发明人： Rachel PERRET ,  Philip D. GREENBERG ,  Thomas M. SCHMITT ,  Aude G. CHAPUIS ,  Ingunn M. STROMNES ,  Tijana MARTINOV

IPC分类号： A61K38/17 ,  A61K35/17 ,  A61P35/00

摘要： The present disclosure provides compositions and methods for targeting a Ras antigen to, for example, treat or prevent cancer. Disclosed embodiments include binding proteins, such as a T cell receptor or a chimeric antigen receptor, that bind to a Ras antigen:HLA complex. Polynucleotides encoding such binding protein can introduced into a host cell, such as a T cell, and the cell can be used in immunotherapy for treating various cancers. Also provided are immunogenic polypeptides that can be useful to, for example, induce an immune response against a mutated Ras or to identify a binding protein that binds to a Ras antigen.