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公开(公告)号:US20140363461A1
公开(公告)日:2014-12-11
申请号:US14240616
申请日:2012-08-31
申请人: Fabio Bagnoli , Barbara Baudner , Simone Bufali
发明人: Fabio Bagnoli , Barbara Baudner , Simone Bufali
IPC分类号: A61K39/085 , A61K39/39
CPC分类号: A61K39/085 , A61K39/39 , A61K2039/55505 , A61K2039/55511 , A61K2039/55572
摘要: The efficacy of S. aureus vaccines can be enhanced by adjuvanting S. aureus antigens with a mixture of a TLR agonist (preferably a TLR7 agonist) and an insoluble metal salt (preferably an aluminium salt). The TLR agonist is typically adsorbed to the metal salt. A S. aureus antigen can also be adsorbed to the metal salt.
摘要翻译: 金黄色葡萄球菌疫苗的功效可以通过用TLR激动剂(优选TLR7激动剂)和不溶性金属盐(优选铝盐)的混合物佐剂金黄色葡萄球菌抗原来增强。 TLR激动剂通常被吸附到金属盐上。 金黄色葡萄球菌抗原也可以被吸附到金属盐上。