公开(公告)号：US08299233B2

公开(公告)日：2012-10-30

申请号：US12811792

申请日：2009-01-05

申请人： Fabrice Andre ,  Stefan Michiels ,  Suzette Delaloge ,  Marc Spielmann ,  Philippe Dessen ,  Philippe Vielh

发明人： Fabrice Andre ,  Stefan Michiels ,  Suzette Delaloge ,  Marc Spielmann ,  Philippe Dessen ,  Philippe Vielh

IPC分类号： C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/156

摘要： The invention relates to the use of a multiplicity of polynucleotide probe sets, the multiplicity of polynucleotide probe sets consisting in a combination of pools of polynucleotide probe sets, each polynucleotide probe set containing at least one polynucleotide probe chosen among a library of nucleic acid sequences, the polynucleotide probes involved in the combination of pools of polynucleotide probe sets of the multiplicity of polynucleotide probe sets being such that each polynucleotide probe specifically hybridizes with one gene, and/or at least one of its variants when present, for determining the variation of expression at least 12 genes, and their variants when present, in order to diagnose the benign or malignant state of a breast tumor.

摘要翻译： 本发明涉及多种多核苷酸探针组的使用，多核苷酸探针组由多核苷酸探针组的组合组成，每个多核苷酸探针组含有选自核酸序列文库中的至少一种多核苷酸探针， 涉及多个多核苷酸探针组的多核苷酸探针组的组合的多核苷酸探针使得每个多核苷酸探针与一个基因和/或其存在的至少一个变体特异性杂交用于确定表达的变化 至少12个基因及其变异体，以便诊断乳腺肿瘤的良性或恶性状态。

公开(公告)号：US20110009286A1

公开(公告)日：2011-01-13

申请号：US12811792

申请日：2009-01-05

申请人： Fabrice Andre ,  Stefan Michiels ,  Suzette Delaloge ,  Marc Spielmann ,  Philippe Dessen ,  Philippe Vielh

发明人： Fabrice Andre ,  Stefan Michiels ,  Suzette Delaloge ,  Marc Spielmann ,  Philippe Dessen ,  Philippe Vielh

IPC分类号： C40B30/04 ,  C40B40/06

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/156

摘要： The invention relates to the use of a multiplicity of polynucleotide probe sets, the multiplicity of polynucleotide probe sets consisting in a combination of pools of polynucleotide probe sets, each polynucleotide probe set containing at least one polynucleotide probe chosen among a library of nucleic acid sequences, the polynucleotide probes involved in the combination of pools of polynucleotide probe sets of the multiplicity of polynucleotide probe sets being such that each polynucleotide probe specifically hybridizes with one gene, and/or at least one of its variants when present, for determining the variation of expression at least 12 genes, and their variants when present, in order to diagnose the benign or malignant state of a breast tumor.

摘要翻译： 本发明涉及多种多核苷酸探针组的使用，多核苷酸探针组由多核苷酸探针组的组合组成，每个多核苷酸探针组含有选自核酸序列文库中的至少一种多核苷酸探针， 涉及多个多核苷酸探针组的多核苷酸探针组的组合的多核苷酸探针使得每个多核苷酸探针与一个基因和/或其存在的至少一个变体特异性杂交用于确定表达的变化 至少12个基因及其变异体，以便诊断乳腺肿瘤的良性或恶性状态。