专利检索 ap:("Federico C. A. Gaeta" OR "Andrew Baird" OR "Jerry Anchin" OR "Wenbin Ying" OR "Robert Florkiewicz" OR "Jagadish Sircar" OR "Sunil Mumar K. C.") AND inv:"Sunil Mumar K. C." 第 1 页

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发明授权
Inhibitors of macrophage migration inhibitory factor and methods for identifying the same 失效

公开(公告)号：US07105519B2

公开(公告)日：2006-09-12

申请号：US10156650

申请日：2002-05-24

申请人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Mumar K. C.

发明人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Mumar K. C.

IPC分类号： A61K31/496 , C07D403/04 , C07D405/14 , C07D409/14

CPC分类号： C07D401/12 , C07D215/42 , C07D215/54 , C07D405/12 , C07D409/12

摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.