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1.发明授权Basic non-peptide bradykinin antagonists and pharmaceutical compositions therefrom 有权碱性非肽缓激肽拮抗剂及其药物组合物公开(公告)号：US07491825B2
公开(公告)日：2009-02-17
申请号：US10516681
申请日：2003-06-05
申请人： Federico Calvani , Fernando Catrambone , Patrizia Felicetti , Christopher Ingo Fincham , Alessandro Giolitti , Carlo Alberto Maggi , Laura Quartara , Cristina Rossi , Rosa Terracciano
发明人： Federico Calvani , Fernando Catrambone , Patrizia Felicetti , Christopher Ingo Fincham , Alessandro Giolitti , Carlo Alberto Maggi , Laura Quartara , Cristina Rossi , Rosa Terracciano
IPC分类号： C07D215/38 , A61K31/47
CPC分类号： C07D401/12 , C07D215/26
摘要： Non-peptide compounds of formula (I) having activity as specific antagonists of bradykinin (BK) B2 receptor. The compounds are chemically characterized by the presence of an alpha, alpha-disubstituted amino acid at least one amino group, free or salified, or the corresponding ammonium quaternary salt. These BK receptor antagonists are a novel class of medicaments which can be used in all the disorders in which the receptors are involved.
摘要翻译： 具有活性作为缓激肽（BK）B2受体的特异性拮抗剂的式（I）的非肽化合物。 化合物的化学特征在于存在α，α-二取代的氨基酸至少一个氨基，游离或盐化，或相应的铵季盐。 这些BK受体拮抗剂是一类新型的药物，可用于涉及受体的所有疾病。
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2.发明申请Basic non-peptide bradykinin antagonists and pharmaceutical compositions therefrom 有权碱性非肽缓激肽拮抗剂及其药物组合物公开(公告)号：US20060205712A1
公开(公告)日：2006-09-14
申请号：US10516681
申请日：2003-06-05
申请人： Federico Calvani , Fernando Catrambone , Patrizia Felicetti , Christopher Fincham , Alessandro Giolitti , Carlo Maggi , Laura Quartara , Cristina Rossi , Rosa Terracciano
发明人： Federico Calvani , Fernando Catrambone , Patrizia Felicetti , Christopher Fincham , Alessandro Giolitti , Carlo Maggi , Laura Quartara , Cristina Rossi , Rosa Terracciano
IPC分类号： A61K31/551 , A61K31/496 , A61K31/4709 , C07D403/02 , C07D401/02
CPC分类号： C07D401/12 , C07D215/26
摘要： Non-peptide compounds of formula (I) having activity as specific antagonists of bradykinin (BK) B2 receptor. The compounds are chemically characterized by the presence of an alpha, alpha-disubstituted amino acid at least one amino group, free or salified, or the corresponding ammonium quaternary salt. These BK receptor antagonists are a novel class of medicaments which can be used in all the disorders in which said receptors are involved
摘要翻译： 具有活性作为缓激肽（BK）B2受体的特异性拮抗剂的式（I）的非肽化合物。 化合物的化学特征在于存在α，α-二取代的氨基酸至少一个氨基，游离或盐化，或相应的铵季盐。 这些BK受体拮抗剂是一类新的药物，可用于所有受体参与的所有疾病中
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