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1.发明公开公开(公告)号：US20240066058A1
公开(公告)日：2024-02-29
申请号：US18259175
申请日：2022-01-10
申请人： Fedor ZOTOV
发明人： Lyudmila Nikolaevna SHIYAN , Galina Leonidovna LOBANOVA , Alexey Vitalievich PUSTOVALOV , Mikhail Alexandrovich BULDAKOV , Tatiana Alexandrovna YURMAZOVA , Fedor ZOTOV , Dmitry Igorevich SHVARTSMAN , Anastasia Alekseevna EVTINA
CPC分类号： A61K33/26 , A61P35/00 , B22F1/052 , B22F1/056 , B22F1/147 , B22F9/14 , B22F2301/35 , B22F2304/054 , B22F2304/10 , B22F2998/10
摘要： The given invention is related to the field of medicine, namely to experimental research in oncology, and can be used to obtain a pharmaceutical agent for inhibiting the proliferation of HeLa cervical cancer cells. It entails the use of a metal powder obtained in a gaseous medium by means of an electric explosion of a wire made of low-carbon steel carried out with a specific energy of 7-18 kJ/g and a pulse duration of 1.2-2 μs. The explosion is carried out inside a reactor that is pre-evacuated to a residual pressure of 10−2 Pa, and then filled with carbon monoxide to a pressure of 105 Pa at a gas circulation rate flow of 10 m/s. The products of the explosion deposited in a hopper are passivated in air for at least 48 hours. The resulting powder is extracted and mixed with a solution of the RPMI-1640 nutrient medium with L-glutamine, a pH of 7.2, in the proportion of the mass of the powder to the volume of the specified solution from 1:10 to 2.7:10. The solution is then centrifuged until the phases are separated. The liquid phase is decanted and used as a pharmaceutical agent. The purpose of the given invention is to expand the arsenal of tools for inhibiting the proliferation of tumor cells.
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2.发明公开公开(公告)号：US20240051020A1
公开(公告)日：2024-02-15
申请号：US18259171
申请日：2022-01-10
申请人： Fedor ZOTOV
发明人： Lyudmila Nikolaevna SHIYAN , Galina Leonidovna LOBANOVA , Alexey Vitalievich PUSTOVALOV , Mikhail Alexandrovich BULDAKOV , Tatiana Alexandrovna YURMAZOVA , Fedor ZOTOV , Dmitry Igorevich SHVARTSMAN
CPC分类号： B22F9/14 , B22F1/054 , B22F9/04 , B22F2201/04 , B22F2304/10 , B22F2999/00
摘要： A method for producing a metal powder, comprising an electric explosion of a piece of a steel wire carried out inside a reactor at a pressure of a gaseous medium of 105 Pa and its forced circulation, characterized in that the method further comprises a pre-evacuation of a volume contained inside the reactor and pipes connecting it to a cyclone, whose lower part is equipped with a hopper, to a residual pressure of 10−2 Pa, then it is filled with carbon monoxide to a pressure of 105 Pa at a gas flow rate of 10 m/s at a reactor inlet, the electric explosion of the steel wire made of low-carbon steel is then carried out at a specific energy of 7-18 kj/g and a pulse duration of 1.2-2 μs, products of the electric explosion are extracted by gas flow through the cyclone into the hopper to deposit, once the hopper is filled, the process is halted, the hopper is disconnected from the cyclone, closed with a lid with an opening, and kept in this state for at least 48 hours, the resulting powder is then removed and placed into a container for storage.
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