公开(公告)号：US20200255528A1

公开(公告)日：2020-08-13

申请号：US16814627

申请日：2020-03-10

申请人： Five Prime Therapeutics, Inc.

发明人： Charles KAPLAN ,  Derrick HOUSER ,  Luis BORGES ,  Gloria BRATTICH ,  David BELLOVIN ,  Felicia KEMP ,  Majid GHODDUSI ,  Nels P. NIELSON ,  Kathy MILLER ,  Maike SCHMIDT

IPC分类号： C07K16/28 ,  G01N33/574 ,  A61P35/00

摘要： The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4 (and optionally cynomolgus monkey, mouse, and/or rat B7-H4) and compositions comprising such antibodies or antigen-binding fragments thereof. In a specific aspect, the antibodies or antigen-binding fragments thereof that specifically bind to human B7-H4 increase T cell proliferation, increase interferon-gamma production, and/or deplete B7-H4 expressing cells via ADCC activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody or antigen-binding fragment thereof that specifically binds to human B7-H4.