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1.发明申请公开(公告)号：US20200185053A1
公开(公告)日：2020-06-11
申请号：US16733013
申请日：2020-01-02
发明人： Shahrooz Rabizadeh , John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Patrick Soon-Shiong
摘要： Omics patient data are analyzed using sequences or diff objects of tumor and matched normal tissue to identify patient and disease specific mutations, using transcriptomic data to identify expression levels of the mutated genes, and pathway analysis based on the so obtained omic data to identify specific pathway characteristics for the diseased tissue. Most notably, many different tumors have shared pathway characteristics, and identification of a pathway characteristic of a tumor may thus indicate effective treatment options ordinarily not considered when tumor analysis is based on anatomical tumor type only.
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公开(公告)号：US10176295B2
公开(公告)日：2019-01-08
申请号：US14499023
申请日：2014-09-26
发明人： John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Shahrooz Rabizadeh , Nicole Hensley , Patrick Soon-Shiong
IPC分类号： G06F19/22
摘要： Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format.
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公开(公告)号：US11361844B2
公开(公告)日：2022-06-14
申请号：US16032421
申请日：2018-07-11
发明人： John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Shahrooz Rabizadeh , Nicole Hensley , Patrick Soon-Shiong
摘要： Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format.
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公开(公告)号：US20220277809A1
公开(公告)日：2022-09-01
申请号：US17739792
申请日：2022-05-09
申请人： Five3 Genomics, LLC
发明人： John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Shahrooz Rabizadeh , Nicole Hensley , Patrick Soon-Shiong
摘要： Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format.
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公开(公告)号：US20190392921A1
公开(公告)日：2019-12-26
申请号：US16562186
申请日：2019-09-05
申请人： Five3 Genomics, LLC
发明人： John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Shahrooz Rabizadeh , Nicole Hensley , Patrick Soon-Shiong
IPC分类号： G16B30/00
摘要： Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format.
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公开(公告)号：US20180322245A1
公开(公告)日：2018-11-08
申请号：US16032421
申请日：2018-07-11
发明人： John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Shahrooz Rabizadeh , Nicole Hensley , Patrick Soon-Shiong
IPC分类号： G06F19/22
CPC分类号： G06F19/22
摘要： Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format.
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7.发明申请Systems And Methods For Comprehensive Analysis Of Molecular Profiles Across Multiple Tumor And Germline Exomes 审中-公开用于多个肿瘤和种系异常的分子谱综合分析的系统和方法公开(公告)号：US20160026752A1
公开(公告)日：2016-01-28
申请号：US14726930
申请日：2015-06-01
申请人： Five3 Genomics, LLC
发明人： Shahrooz Rabizadeh , John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Patrick Soon-Shiong
摘要： Omics patient data are analyzed using sequences or diff objects of tumor and matched normal tissue to identify patient and disease specific mutations, using transcriptomic data to identify expression levels of the mutated genes, and pathway analysis based on the so obtained omic data to identify specific pathway characteristics for the diseased tissue. Most notably, many different tumors have shared pathway characteristics, and identification of a pathway characteristic of a tumor may thus indicate effective treatment options ordinarily not considered when tumor analysis is based on anatomical tumor type only.
摘要翻译： 使用肿瘤和匹配的正常组织的序列或diff对象来分析肿瘤患者数据，以鉴定患者和疾病特异性突变，使用转录组学数据来鉴定突变基因的表达水平，以及基于如此获得的omic数据以鉴定特异性途径的途径分析 病变组织的特征。 最值得注意的是，许多不同的肿瘤具有共享的通路特征，并且鉴定肿瘤特征的途径可能表明当肿瘤分析仅基于解剖肿瘤类型时通常不被考虑的有效治疗方案。
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公开(公告)号：US20150088432A1
公开(公告)日：2015-03-26
申请号：US14499023
申请日：2014-09-26
发明人： John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Shahrooz Rabizadeh , Nicole Hensley , Patrick Soon-Shiong
CPC分类号： G06F19/22
摘要： Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format.
摘要翻译： 考虑的系统和方法使用嵌合参考序列，其包括多个病毒基因组序列以鉴定/定量整合和共扩增事件。 最典型地，病毒基因组序列作为单个染色体组织在嵌合参考序列中，并且嵌合参考序列是BAM格式。
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