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公开(公告)号：US07235364B2
公开(公告)日：2007-06-26
申请号：US11398208
申请日：2006-04-04
申请人： Florian Lang , Siegfried Waldegger , Philipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
发明人： Florian Lang , Siegfried Waldegger , Philipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a method for diagnosing hypertension, and/or allergy, and/or hair loss, and/or liabilty for infection, of a human being, or a predisposition therefor; to a nucleic acid molecule coding for a human ClCKb protein comprising a genetic alteration at amino acid position 481 compared to the wild type, as well as for corresponding segments thereof; to a nucleic acid molecule which binds to the before-mentioned nucleic acid molecule under stringent conditions, as well as to a nucleic acid molecule which binds to that nucleic acid molecule; to a (poly)peptide encoded by the afore-mentioned nucleic acid molecules; to a method for identifying substances modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to a substance for modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to methods for preparing a pharmaceutical composition for treatment of hypertension, and/or allergy, and/or hair loss, and/or liability for infection; to pharmaceutical compositions; and to a method for treating a human being affected by hypertension, and/or allergy and/or hair loss, and/or liability for infection.
摘要翻译： 本发明涉及一种用于诊断人类或其易感性的高血压，/或过敏和/或脱发，和/或感染的可能性的方法; 涉及编码人类ClCKb蛋白质的核酸分子，其包含与野生型相比在氨基酸位置481处的遗传改变，以及其对应的片段; 涉及在严格条件下与前述核酸分子结合的核酸分子，以及与该核酸分子结合的核酸分子; 涉及由上述核酸分子编码的（多）肽; 涉及一种用于鉴定与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽调节活性的物质的方法; 涉及调节与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽的活性的物质; 制备用于治疗高血压和/或过敏和/或脱发的药物组合物和/或感染责任的方法; 至药物组合物; 以及治疗受高血压，/或过敏和/或脱发影响的人的方法和/或感染责任。
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公开(公告)号：US20050084485A1
公开(公告)日：2005-04-21
申请号：US10687523
申请日：2003-10-15
申请人： Florian Lang , Siegfried Waldegger , Philipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
发明人： Florian Lang , Siegfried Waldegger , Philipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a method for diagnosing hypertension, and/or allergy, and/or hair loss, and/or liabilty for infection, of a human being, or a predisposition therefor; to a nucleic acid molecule coding for a human ClCKb protein comprising a genetic alteration at amino acid position 481 compared to the wild type, as well as for corresponding segments thereof; to a nucleic acid molecule which binds to the before-mentioned nucleic acid molecule under stringent conditions, as well as to a nucleic acid molecule which binds to that nucleic acid molecule; to a (poly)peptide encoded by the afore-mentioned nucleic acid molecules; to a method for identifying substances modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to a substance for modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to methods for preparing a pharmaceutical composition for treatment of hypertension, and/or allergy, and/or hair loss, and/or liability for infection; to pharmaceutical compositions; and to a method for treating a human being affected by hypertension, and/or allergy and/or hair loss, and/or liability for infection.
摘要翻译： 本发明涉及一种用于诊断人类或其易感性的高血压，/或过敏和/或脱发，和/或感染的可能性的方法; 涉及编码人类ClCKb蛋白质的核酸分子，其包含与野生型相比在氨基酸位置481处的遗传改变，以及其对应的片段; 涉及在严格条件下与前述核酸分子结合的核酸分子，以及与该核酸分子结合的核酸分子; 涉及由上述核酸分子编码的（多）肽; 涉及一种用于鉴定与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽调节活性的物质的方法; 涉及调节与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽的活性的物质; 制备用于治疗高血压和/或过敏和/或脱发的药物组合物和/或感染责任的方法; 至药物组合物; 以及治疗受高血压，/或过敏和/或脱发影响的人的方法和/或感染责任。
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公开(公告)号：US20060240459A1
公开(公告)日：2006-10-26
申请号：US11398208
申请日：2006-04-04
申请人： Florian Lang , Siegfried Waldegger , Philipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
发明人： Florian Lang , Siegfried Waldegger , Philipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a method for diagnosing hypertension, and/or allergy, and/or hair loss, and/or liabilty for infection, of a human being, or a predisposition therefor; to a nucleic acid molecule coding for a human ClCKb protein comprising a genetic alteration at amino acid position 481 compared to the wild type, as well as for corresponding segments thereof; to a nucleic acid molecule which binds to the before-mentioned nucleic acid molecule under stringent conditions, as well as to a nucleic acid molecule which binds to that nucleic acid molecule; to a (poly)peptide encoded by the afore-mentioned nucleic acid molecules; to a method for identifying substances modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to a substance for modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to methods for preparing a pharmaceutical composition for treatment of hypertension, and/or allergy, and/or hair loss, and/or liability for infection; to pharmaceutical compositions; and to a method for treating a human being affected by hypertension, and/or allergy and/or hair loss, and/or liability for infection.
摘要翻译： 本发明涉及一种用于诊断人类或其易感性的高血压，/或过敏和/或脱发，和/或感染的可能性的方法; 涉及编码人类ClCKb蛋白质的核酸分子，其包含与野生型相比在氨基酸位置481处的遗传改变，以及其对应的片段; 涉及在严格条件下与前述核酸分子结合的核酸分子，以及与该核酸分子结合的核酸分子; 涉及由上述核酸分子编码的（多）肽; 涉及一种用于鉴定与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽调节活性的物质的方法; 涉及调节与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽的活性的物质; 制备用于治疗高血压和/或过敏和/或脱发的药物组合物和/或感染责任的方法; 至药物组合物; 以及治疗受高血压，/或过敏和/或脱发影响的人的方法和/或感染责任。
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公开(公告)号：US07074573B2
公开(公告)日：2006-07-11
申请号：US10687523
申请日：2003-10-15
申请人： Florian Lang , Siegfried Waldegger , Phillipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
发明人： Florian Lang , Siegfried Waldegger , Phillipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a method for diagnosing hypertension, and/or allergy, and/or hair loss, and/or liability for infection, of a human being, or a predisposition therefor; to a nucleic acid molecule coding for a human ClCKb protein comprising a genetic alteration at amino acid position 481 compared to the wild type, as well as for corresponding segments thereof; to a nucleic acid molecule which binds to the before-mentioned nucleic acid molecule under stringent conditions, as well as to a nucleic acid molecule which binds to that nucleic acid molecule; to a (poly)peptide encoded by the afore-mentioned nucleic acid molecules; to a method for identifying substances modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to a substance for modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to methods for preparing a pharmaceutical composition for treatment of hypertension, and/or allergy, and/or hair loss, and/or liability for infection; to pharmaceutical compositions; and to a method for treating a human being affected by hypertension, and/or allergy and/or hair loss, and/or liability for infection.
摘要翻译： 本发明涉及一种用于诊断人类或其易感性的高血压，/或过敏和/或脱发，和/或感染责任的方法; 涉及编码人类ClCKb蛋白质的核酸分子，其包含与野生型相比在氨基酸位置481处的遗传改变，以及其对应的片段; 涉及在严格条件下与前述核酸分子结合的核酸分子，以及与该核酸分子结合的核酸分子; 涉及由上述核酸分子编码的（多）肽; 涉及一种用于鉴定与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽调节活性的物质的方法; 涉及调节与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽的活性的物质; 制备用于治疗高血压和/或过敏和/或脱发的药物组合物和/或感染责任的方法; 至药物组合物; 以及治疗受高血压，/或过敏和/或脱发影响的人的方法和/或感染责任。
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