公开(公告)号：US20040234574A9

公开(公告)日：2004-11-25

申请号：US10338933

申请日：2003-01-07

申请人： Focal, Inc.

发明人： Amarpreet S. Sawhney ,  Michelle D. Lyman ,  Peter K. Jarrett ,  Ronald S. Rudowsky

IPC分类号： A61F002/00

CPC分类号： A61L31/06 ,  A61K9/1635 ,  A61K9/1647 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L31/10 ,  A61L31/148 ,  C08G63/64 ,  C08G63/676 ,  C08L67/04

摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.

摘要翻译： 公开了与施加的表面高度附着的改进的屏障或药物递送系统，以及用于制造屏障的方法。 在优选实施例中，该系统是符合的，因为当组织在愈合过程中弯曲并变形时，其能够符合组织表面的三维结构。 通过将可聚合单体施加到表面上，然后聚合单体，将屏障或药物递送系统形成为组织表面上的聚合物涂层。 聚合的柔顺涂层优选是可生物降解和生物相容的，并且可以设计成具有选择的适应性和弹性性质，用于不同的手术和治疗应用。

公开(公告)号：US20020151650A1

公开(公告)日：2002-10-17

申请号：US10114722

申请日：2002-04-02

申请人： Focal, Inc.

发明人： Chandrashekhar P. Pathak ,  Shikha P. Barman ,  C. Michael Philbrook ,  Amarpreet S. Sawhney ,  Arthur J. Coury ,  Luis Z. Avila ,  Mark T. Kieras

IPC分类号： C08L053/00

CPC分类号： A61K9/5138 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/1274 ,  A61K9/146 ,  A61K9/2027 ,  A61K9/5146 ,  A61K9/7015 ,  A61K47/32 ,  A61K47/34 ,  A61L15/58 ,  A61L15/60 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  C08G63/00 ,  C08G65/329 ,  C08L71/02 ,  Y10S424/13 ,  Y10S524/916 ,  Y10S525/941 ,  C08L71/00 ,  C08L2666/14

摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.

摘要翻译： 提供包含至少四个聚合物嵌段的凝胶形成大分子单体，其中至少两个是疏水性的，并且其中至少一个是亲水的，并且包括可交联基团。 大分子单体可以共价交联以在体内在组织表面上形成凝胶。 由大分子单体形成的凝胶具有包括热敏性和亲油性的性质的组合，并且可用于各种医疗应用，包括药物递送和组织包衣。

公开(公告)号：US20040072961A1

公开(公告)日：2004-04-15

申请号：US10650163

申请日：2003-08-27

申请人： Focal, Inc

发明人： Chandrashekhar P. Pathak ,  Shikha P. Barman ,  C. Michael Philbrook ,  Amarpreet S. Sawhney ,  Arthur J. Coury ,  Luis Z. Avila ,  Mark T. Kieras

IPC分类号： C08G081/00

CPC分类号： A61K9/5138 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/1274 ,  A61K9/146 ,  A61K9/2027 ,  A61K9/5146 ,  A61K9/7015 ,  A61K47/32 ,  A61K47/34 ,  A61L15/58 ,  A61L15/60 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  C08G63/00 ,  C08G65/329 ,  C08L71/02 ,  Y10S424/13 ,  Y10S524/916 ,  Y10S525/941 ,  C08L71/00 ,  C08L2666/14

摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.

摘要翻译： 提供包含至少四个聚合物嵌段的凝胶形成大分子单体，其中至少两个是疏水性的，并且其中至少一个是亲水的，并且包括可交联基团。 大分子单体可以共价交联以在体内在组织表面上形成凝胶。 由大分子单体形成的凝胶具有包括热敏性和亲油性的性质的组合，并且可用于各种医疗应用，包括药物递送和组织包衣。

公开(公告)号：US20030104032A1

公开(公告)日：2003-06-05

申请号：US10338933

申请日：2003-01-07

申请人： Focal, Inc.

发明人： Amarpreet S. Sawhney ,  Michelle D. Lyman ,  Peter K. Jarrett ,  Ronald S. Rudowsky

IPC分类号： A61F002/00

CPC分类号： A61L31/06 ,  A61K9/1635 ,  A61K9/1647 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L31/10 ,  A61L31/148 ,  C08G63/64 ,  C08G63/676 ,  C08L67/04

摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.