公开(公告)号：US20190142842A1

公开(公告)日：2019-05-16

申请号：US16243842

申请日：2019-01-09

Applicant: ForSight Vision5, Inc.

Inventor： Logan Stark ,  Rachna Jain ,  Ravi Srinivasan ,  Cary J. Reich ,  Carlos Schuler

IPC: A61K31/5575 ,  A61K9/00 ,  A61K47/34

Abstract: The present disclosure includes compositions of a semi-crystalline or crystalline pharmaceutically active agent dispersed in a polymer matrix, in which the active agent is less degraded and, therefore, has lower level of impurities. The present disclosure further includes a method of reducing or preventing physical and chemical degradation of a semi-crystalline or crystalline active agent pharmaceutically active agent dispersed in a polymer matrix. A method of preparation of the composition is also included in this disclosure.

公开(公告)号：US20160022695A1

公开(公告)日：2016-01-28

申请号：US14775989

申请日：2014-03-27

Applicant: FORSIGHT VISION5, INC.

Inventor： Cary Reich ,  Carlos Schuler ,  Qiang Ye ,  Logan Stark ,  Rachna Jain

IPC: A61K31/5575 ,  A61K9/00 ,  A61K47/34

CPC classification number: A61K31/5575 ,  A61F9/0017 ,  A61K9/0051 ,  A61K9/70 ,  A61K47/34 ,  A61L27/18 ,  A61L27/48 ,  A61L27/54 ,  C08L83/04

Abstract: The present invention is directed to compositions of bimatoprost, processes of preparing these compositions, devices comprising these compositions, and methods of lowering intraocular pressure.

Abstract translation: 本发明涉及比马前列素的组合物，制备这些组合物的方法，包含这些组合物的装置以及降低眼内压的方法。

公开(公告)号：US20180092926A1

公开(公告)日：2018-04-05

申请号：US15725145

申请日：2017-10-04

Applicant: ForSight Vision5, Inc.

Inventor： Cary J. Reich ,  Carlos Schuler ,  Qiang Ye ,  Logan Stark ,  Rachna Jain

IPC: A61K31/5575 ,  A61L27/18 ,  A61L27/54 ,  A61L27/48 ,  A61F9/00 ,  A61K47/34 ,  A61K9/70 ,  A61K9/00 ,  C08L83/04

CPC classification number: A61K31/5575 ,  A61F9/0017 ,  A61K9/0051 ,  A61K9/70 ,  A61K47/34 ,  A61L27/18 ,  A61L27/48 ,  A61L27/54 ,  C08L83/04

Abstract: The present invention is directed to compositions of bimatoprost, processes of preparing these compositions, devices comprising these compositions, and methods of lowering intraocular pressure.

公开(公告)号：US20220331335A1

公开(公告)日：2022-10-20

申请号：US17535000

申请日：2021-11-24

Applicant: ForSight Vision5, Inc.

Inventor： Cary J. Reich ,  Carlos Schuler ,  Qiang Ye ,  Logan Stark ,  Rachna Jain

IPC: A61K31/5575 ,  A61K9/00 ,  A61L27/18 ,  A61L27/48 ,  A61L27/54 ,  A61F9/00 ,  A61K9/70 ,  A61K47/34

Abstract: The present invention is directed to compositions of bimatoprost, processes of preparing these compositions, devices comprising these compositions, and methods of lowering intraocular pressure.

公开(公告)号：US20220331336A1

公开(公告)日：2022-10-20

申请号：US17542838

申请日：2021-12-06

Applicant: ForSight Vision5, Inc.

Inventor： Logan Stark ,  Rachna Jain ,  Ravi Srinivasan ,  Cary J. Reich ,  Carlos Schuler

IPC: A61K31/5575 ,  A61K9/00 ,  A61K47/34

Abstract: The present disclosure includes compositions of a semi-crystalline or crystalline pharmaceutically active agent dispersed in a polymer matrix, in which the active agent is less degraded and, therefore, has lower level of impurities. The present disclosure further includes a method of reducing or preventing physical and chemical degradation of a semi-crystalline or crystalline active agent pharmaceutically active agent dispersed in a polymer matrix. A method of preparation of the composition is also included in this disclosure.

公开(公告)号：US20160296532A1

公开(公告)日：2016-10-13

申请号：US15096329

申请日：2016-04-12

Applicant: ForSight Vision5, Inc.

Inventor： Logan Stark ,  Rachna Jain ,  Ravi Srinivasan ,  Cary J. Reich ,  Carlos Schuler

IPC: A61K31/5575 ,  A61K47/34 ,  A61K9/00

CPC classification number: A61K31/5575 ,  A61K9/0051 ,  A61K47/34

Abstract: The present disclosure includes compositions of a semi-crystalline or crystalline pharmaceutically active agent dispersed in a polymer matrix, in which the active agent is less degraded and, therefore, has lower level of impurities. The present disclosure further includes a method of reducing or preventing physical and chemical degradation of a semi-crystalline or crystalline active agent pharmaceutically active agent dispersed in a polymer matrix. A method of preparation of the composition is also included in this disclosure.

Abstract translation: 本公开内容包括分散在聚合物基质中的半结晶或结晶药物活性剂的组合物，其中活性剂较少降解，因此具有较低水平的杂质。 本公开还包括减少或防止分散在聚合物基质中的半结晶或结晶活性剂药物活性剂的物理和化学降解的方法。 组合物的制备方法也包括在本公开中。