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公开(公告)号：US10344053B2
公开(公告)日：2019-07-09
申请号：US15535002
申请日：2015-12-11
发明人： Ronald Kühne , Hans-Günther Schmalz , Matthias Müller , Cedric Reuter , Arne Soicke , Robert Opitz , Matthias Barone , Hartmut Oschkinat
IPC分类号： A61K31/55 , C07D471/10 , C07K7/06 , C07D519/00 , A61K38/00
摘要： The present invention relates to chemical compounds that can in particular be used as structural mimetics of proline-rich peptides. The compounds of the present invention are capable of selectively inhibiting ena/VASP-EVH1-mediated protein-protein interactions. The invention further relates to the use of said compounds as pharmaceutical agents and to the use of the pharmaceutical agents to treat tumor diseases. The chemical compounds of the present invention can significantly inhibit the chemotaxis and motility of invasive tumor cells and can therefore be used in the treatment and/or prevention of tumor metastases.
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公开(公告)号：US20210332050A1
公开(公告)日：2021-10-28
申请号：US16975346
申请日：2019-02-26
发明人： Ronald Kühne , Hans-Günther Schmalz , Stephan Dohmen , Matthias Barone , Matthias Müller , Slim Chiha , Dominik Albat
IPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to chemical compounds which can be used in particular as structural mimetics of proline-rich peptides. The compounds of the present invention are capable of selectively inhibiting Ena/VASP-EVH1-mediated protein-protein interactions. The invention further relates to the use of these compounds as pharmaceutical agents and the use of the pharmaceutical agents for the treatment of tumor diseases.
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