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![Crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate](/abs-image/US/2017/01/24/US09550767B2/abs.jpg.150x150.jpg)
1.发明授权Crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate 有权（R）-7-氯-N-（奎宁环-3-基）苯并[b]噻吩-2-甲酰胺盐酸盐一水合物的结晶形式公开(公告)号：US09550767B2
公开(公告)日：2017-01-24
申请号：US15002163
申请日：2016-01-20
发明人： Patricia Oliver-Shaffer , Gideon Shapiro , Richard Chesworth , Muneki Kishida , Takayuki Ishige
IPC分类号： C07D453/02 , A61K9/48 , A61K31/439 , C30B29/54
CPC分类号： C07D453/02 , A61K9/4833 , A61K31/439 , C07B2200/13 , C30B29/54
摘要： Crystalline Forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate and compositions, methods of manufacture and therapeutic uses thereof are described.
摘要翻译： （R）-7-氯-N-（奎宁环-3-基）苯并[b]噻吩-2-甲酰胺盐酸盐一水合物的结晶形式I和II及其制备方法及其治疗用途。
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![Crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate](/abs-image/US/2016/03/01/US09273044B2/abs.jpg.150x150.jpg)
2.发明授权Crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate 有权（R）-7-氯-N-（奎宁环-3-基）苯并[b]噻吩-2-甲酰胺盐酸盐一水合物的结晶形式公开(公告)号：US09273044B2
公开(公告)日：2016-03-01
申请号：US14795595
申请日：2015-07-09
发明人： Patricia Oliver-Shaffer , Gideon Shapiro , Richard Chesworth , Muneki Kishida , Takayuki Ishige
IPC分类号： A61K31/44 , C07D453/02
CPC分类号： C07D453/02 , A61K9/4833 , A61K31/439 , C07B2200/13 , C30B29/54
摘要： Crystalline Forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate and compositions, methods of manufacture and therapeutic uses thereof are described.
摘要翻译： （R）-7-氯-N-（奎宁环-3-基）苯并[b]噻吩-2-甲酰胺盐酸盐一水合物的结晶形式I和II及其制备方法及其治疗用途。
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![Crystalline Form of (R)-7-Chloro-N-(Quinuclidin-3-YL)benzo[B]thiophene-2-Carboxamide Hydrochloride Monohydrate](/abs-image/US/2016/05/19/US20160137638A1/abs.jpg.150x150.jpg)
3.发明申请Crystalline Form of (R)-7-Chloro-N-(Quinuclidin-3-YL)benzo[B]thiophene-2-Carboxamide Hydrochloride Monohydrate 有权（R）-7-氯-N-（奎宁环-3-基）苯并[b]噻吩-2-甲酰胺盐酸盐一水合物的结晶形式公开(公告)号：US20160137638A1
公开(公告)日：2016-05-19
申请号：US15002163
申请日：2016-01-20
发明人： Patricia Oliver-Shaffer , Gideon Shapiro , Richard Chesworth , Muneki Kishida , Takayuki Ishige
IPC分类号： C07D453/02 , A61K31/439 , C30B29/54 , A61K9/48
CPC分类号： C07D453/02 , A61K9/4833 , A61K31/439 , C07B2200/13 , C30B29/54
摘要： Crystalline Forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate and compositions, methods of manufacture and therapeutic uses thereof are described.
摘要翻译： （R）-7-氯-N-（奎宁环-3-基）苯并[b]噻吩-2-甲酰胺盐酸盐一水合物的结晶形式I和II及其制备方法及其治疗用途。
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![Crystalline Form of (R)-7-Chloro-N-(Quinuclidin-3-YL)benzo[B]thiophene-2-Carboxamide Hydrochloride Monohydrate](/abs-image/US/2017/11/02/US20170313694A1/abs.jpg.150x150.jpg)
4.发明申请公开(公告)号：US20170313694A1
公开(公告)日：2017-11-02
申请号：US15375925
申请日：2016-12-12
发明人： Patricia Oliver-Shaffer , Gideon Shapiro , Richard Chesworth , Muneki Kishida , Takayuki Ishige
IPC分类号： C07D453/02 , A61K9/48 , A61K31/439 , C30B29/54
CPC分类号： C07D453/02 , A61K9/4833 , A61K31/439 , C07B2200/13 , C30B29/54
摘要： Crystalline Forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate and compositions, methods of manufacture and therapeutic uses thereof are described.
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![CRYSTALLINE FORM OF (R)-7-CHLORO-N-(QUINUCLIDIN-3-YL)BENZO[B]THIOPHENE-2-CARBOXAMIDE HYDROCHLORIDE MONOHYDRATE](/abs-image/US/2016/01/14/US20160009707A1/abs.jpg.150x150.jpg)
5.发明申请CRYSTALLINE FORM OF (R)-7-CHLORO-N-(QUINUCLIDIN-3-YL)BENZO[B]THIOPHENE-2-CARBOXAMIDE HYDROCHLORIDE MONOHYDRATE 有权（R）-7-氯代-N-（喹啉-3-基）苯并[B]噻吩-2-羧酰胺氢氯化物单盐酸盐的晶体形式公开(公告)号：US20160009707A1
公开(公告)日：2016-01-14
申请号：US14795595
申请日：2015-07-09
发明人： Patricia Oliver-Shaffer , Gideon Shapiro , Richard Chesworth , Muneki Kishida , Takayuki Ishige
IPC分类号： C07D453/02
CPC分类号： C07D453/02 , A61K9/4833 , A61K31/439 , C07B2200/13 , C30B29/54
摘要： Crystalline Forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate and compositions, methods of manufacture and therapeutic uses thereof are described.
摘要翻译： （R）-7-氯-N-（奎宁环-3-基）苯并[b]噻吩-2-甲酰胺盐酸盐一水合物的结晶形式I和II及其制备方法及其治疗用途。
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