公开(公告)号：US20230140123A1

公开(公告)日：2023-05-04

申请号：US17899470

申请日：2022-08-30

Applicant: Foundation Medicine, Inc.

Inventor： Ethan SOKOL ,  Jay MOORE ,  Justin NEWBERG ,  Dexter JIN ,  Kuei-Ting CHEN ,  Russell MADISON

IPC: G16B20/20 ,  C12Q1/6886 ,  G16B20/10 ,  G16B40/20

Abstract: Described herein are methods, devices, and systems for identifying a subset of a plurality of features, using one or more feature importance metrics, for training and using a homologous repair deficiency (HRD) classification model. Further described are methods, devices, and systems for classifying a tumor of a cancer, such as pancreatic cancer, as likely HRD positive or likely HRD negative, and for calling the tumor as HRD positive or HRD negative. Also described herein are methods of treating a tumor of a cancer, such as pancreatic cancer, based on the classifications