公开(公告)号：US20220243279A1

公开(公告)日：2022-08-04

申请号：US17612966

申请日：2020-05-20

Applicant: Foundation Medicine, Inc.

Inventor： Bernard FENDLER ,  Jason D. HUGHES ,  Steven ROELS

IPC: C12Q1/6886 ,  G16B40/20 ,  G16B20/20

Abstract: Disclosed herein are, at least in part, methods of determining a tumor fraction of a sample from a subject. The methods can include, for example, acquiring a value for a target variable associated with a subgenomic interval in the sample; determining, from the target variable, a certainty metric; accessing a determined relationship between a stored certainty metric and a stored tumor fraction; and determining, with reference to the certainty metric and the determined relationship, the tumor fraction of the sample.