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    Synergistic antitumor composition containing a naphthalensulphonic acid derivative
    1.
    发明授权
    Synergistic antitumor composition containing a naphthalensulphonic acid derivative 失效
    含有萘磺酸衍生物的协同抗肿瘤组合物

    公开(公告)号：US06214860B1

    公开(公告)日：2001-04-10

    申请号：US09367853

    申请日：1999-08-30

    申请人： Francesco Sola ,  Maria Grandi

    发明人： Francesco Sola ,  Maria Grandi

    IPC分类号： A61K3140

    CPC分类号： A61K45/06

    摘要： A pharmaceutical composition for use in antineoplastic therapy in mammals, including humans, comprising a biologically active ureido compound of formula (I) wherein each of m and n, being the same, is an integer of 1 to 3; and each of the R groups, which are the same, is a naphthyl group substituted by 1 to 3 sulfonic groups, or a pharmaceutically acceptable salt thereof, and an antineoplastic agent selected from the group consisting of an antineoplastic vinca alkaloid, an antineoplastic antibiotic, an antineoplastic antimetabolite, an antineoplastic platinum coordination complex, an antineoplastic taxane compound, an antineoplastic ceramide compound, an antineoplastic distamycin compound, an antineoplastic epidophyllotoxin compound and an antineoplastic topoisomerase I inhibitor, and a pharmaceutically acceptable carrier or excipient, in amounts effective to produce a synergistic antineoplastic effect, is provided herein.

    摘要翻译： 一种用于哺乳动物（包括人）抗肿瘤治疗的药物组合物，其包含式（I）的生物活性脲基化合物，其中m和n相同，为1至3的整数; 并且相同的R基中的每一个是被1至3个磺酸基取代的萘基或其药学上可接受的盐，以及抗肿瘤剂，其选自抗肿瘤长春花生物碱，抗肿瘤抗生素， 抗肿瘤抗代谢物，抗肿瘤性铂配位络合物，抗肿瘤性紫杉烷化合物，抗肿瘤性神经酰胺化合物，抗肿瘤性霉素化合物，抗肿瘤性表鬼臼毒素化合物和抗肿瘤性拓扑异构酶I抑制剂以及药学上可接受的载体或赋形剂， 协同抗肿瘤作用。