公开(公告)号：US06406689B1

公开(公告)日：2002-06-18

申请号：US09261816

申请日：1999-03-03

申请人： Frank W. Falkenberg ,  Oliver C. Krup

发明人： Frank W. Falkenberg ,  Oliver C. Krup

IPC分类号： A01N6300

CPC分类号： A61K39/0011 ,  A61K2039/5152 ,  A61K2039/55505 ,  A61K2039/55522 ,  Y10S514/963 ,  Y10S514/965

摘要： Compositions and methods are provided which can be utilized in active immunization as a prophylactic treatment or a therapeutic treatment for tumors. The compositions are employed as injectable tumor vaccines or as preparations for intratumoral administration and are capable of stimulating immune responses to specific tumor antigens. The tumor vaccines are composed of an antigenic cellular material including a plurality of inactivated tumor cells or tumor cell portions, a depot material, and an immunostimulant adsorbed to the depot material. The depot material with absorbed immunostimulant is mixed with the tumor cells or tumor cell portions to form the vaccine compositions. The preparations for intratumoral administration include the depot material adsorbed immunostimulant without the antigenic cellular material. The immunostimulant adsorbed to the depot material permits release of biologically active quantities of the immunostimulant over a period of time rather than all at once.

摘要翻译： 提供可用于主动免疫的组合物和方法作为肿瘤的预防治疗或治疗性治疗。 该组合物用作可注射肿瘤疫苗或用于肿瘤内给药的制剂，并且能够刺激对特定肿瘤抗原的免疫应答。 肿瘤疫苗由抗原性细胞材料组成，包括多个灭活的肿瘤细胞或肿瘤细胞部分，贮库材料和吸附于贮库材料的免疫刺激剂。 将具有吸收的免疫刺激剂的储库材料与肿瘤细胞或肿瘤细胞部分混合以形成疫苗组合物。 肿瘤内给药的制剂包括没有抗原性细胞材料的药物吸收的免疫刺激剂。 吸附到贮库材料的免疫刺激剂允许在一段时间内而不是同时全部释放生物活性量的免疫刺激剂。