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公开(公告)号:US08883722B2
公开(公告)日:2014-11-11
申请号:US13805494
申请日:2011-06-21
CPC分类号: C07K14/62
摘要: The present invention is related to human insulin containing additional disulfide bonds and methods of making such.
摘要翻译: 本发明涉及含有另外的二硫键的人胰岛素及其制备方法。
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公开(公告)号:US08853155B2
公开(公告)日:2014-10-07
申请号:US13805774
申请日:2011-06-21
CPC分类号: C07K14/62
摘要: The present invention is related to insulin derivatives containing additional disulfide bonds and methods of making such.
摘要翻译: 本发明涉及含有二硫键的胰岛素衍生物及其制备方法。
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公开(公告)号:US09260502B2
公开(公告)日:2016-02-16
申请号:US12922106
申请日:2009-03-13
申请人: Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Per Balschmidt , Svend Ludvigsen , Thomas Børglum Kjeldsen
发明人: Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Per Balschmidt , Svend Ludvigsen , Thomas Børglum Kjeldsen
摘要: The present invention relates to novel insulin analogs comprising mutations at position A14 in the A chain and at positions B27, B28, B29 and B30 in the B chain and exhibiting resistance towards protease; a method for the preparation of such insulin analogs; insulin preparations containing the insulin analogs of the invention; and, a method of treating diabetes mellitus using these insulin analogs.
摘要翻译: 本发明涉及新的胰岛素类似物,其包含A链A14位和B链位置B27,B28,B29和B30处的突变,并表现出对蛋白酶的抗性; 一种制备这种胰岛素类似物的方法; 含有本发明胰岛素类似物的胰岛素制剂; 以及使用这些胰岛素类似物治疗糖尿病的方法。
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公开(公告)号:US09018161B2
公开(公告)日:2015-04-28
申请号:US12442190
申请日:2007-09-20
申请人: Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Nørgaard , Svend Havelund
发明人: Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Nørgaard , Svend Havelund
摘要: The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the invention and a method of treating diabetes mellitus using these insulin analogues is also provided.
摘要翻译: 本发明涉及对蛋白酶表现出抗性的新型胰岛素类似物,其中至少两个氨基酸相对于母体胰岛素分子被取代和/或缺失。 还提供了制备这种胰岛素类似物的方法,含有本发明的胰岛素类似物的胰岛素制剂和使用这些胰岛素类似物治疗糖尿病的方法。
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公开(公告)号:US20110092419A1
公开(公告)日:2011-04-21
申请号:US12922106
申请日:2009-03-19
申请人: Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Per Balschmidt , Svend Ludvigsen , Thomas Børglum Kjeldsen
发明人: Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Per Balschmidt , Svend Ludvigsen , Thomas Børglum Kjeldsen
摘要: The present invention relates to novel insulin analogues comprising mutations at position A14 in the A chain and at positions B27, B28, B29 and B30 in the B chain and exhibiting resistance towards protease; a method for the preparation of such insulin analogues; insulin preparations containing the insulin analogues of the invention; and, a method of treating diabetes mellitus using these insulin analogues.
摘要翻译: 本发明涉及新的胰岛素类似物,其包含A链A14位和B链位置B27,B28,B29和B30的突变,并表现出对蛋白酶的抗性; 一种制备这种胰岛素类似物的方法; 含有本发明胰岛素类似物的胰岛素制剂; 以及使用这些胰岛素类似物治疗糖尿病的方法。
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公开(公告)号:US20100009898A1
公开(公告)日:2010-01-14
申请号:US12442190
申请日:2007-09-20
申请人: Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Norgaard , Svend Havelund
发明人: Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Norgaard , Svend Havelund
摘要: The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the invention and a method of treating diabetes mellitus using these insulin analogues is also provided.
摘要翻译: 本发明涉及对蛋白酶表现出抗性的新型胰岛素类似物,其中至少两个氨基酸相对于母体胰岛素分子被取代和/或缺失。 还提供了制备这种胰岛素类似物的方法,含有本发明的胰岛素类似物的胰岛素制剂和使用这些胰岛素类似物治疗糖尿病的方法。
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