公开(公告)号：US07717905B2

公开(公告)日：2010-05-18

申请号：US10978613

申请日：2004-11-01

申请人： Frieder Loesel ,  Tobias Kuhn

发明人： Frieder Loesel ,  Tobias Kuhn

IPC分类号： A61F9/008

CPC分类号： A61F9/008 ,  A61F9/00825 ,  A61F2009/00872 ,  A61F2009/00897

摘要： A system and method for performing laser induced optical breakdown (LIOB) in corneal tissue of an eye requires calculating a pattern of focal spots. LIOB is then induced at a first focal spot, and is continued at a plurality of interim focal spots within a time period τ. Each focal spot has a diameter “d1” and generates a temporal cavitation bubble of diameter “d2”. It then collapses within time “τ” to a substantially stationary diameter “d3”, with (d1≦d3≦d2). Importantly, each focal spot is located more than “d2” from every other interim focal spot within the time period of “τ”. At the time “τ”, a second focal spot in the pattern can be generated at a distance “d3” from the first focal spot. This process is then continued with another plurality of interim focal spots being generated within another time period “τ”.

摘要翻译： 用于在眼睛的角膜组织中进行激光诱导光学击穿（LIOB）的系统和方法需要计算焦点的图案。 然后在第一焦点处诱导LIOB，并且在时间段τ内在多个临时焦斑处继续。 每个焦斑具有直径“d1”，并产生直径“d2”的时间空化气泡。 然后在时间“τ”内崩溃到基本上静止的直径“d3”，其中（d1＆nlE; d3＆nlE; d2）。 重要的是，在“τ”的时间段内，每个焦斑位于距离每个其他中间焦点的“d2”以上。 在时间“τ”，可以在与第一焦点相距“d3”的距离处产生图案中的第二焦点。 然后继续在另一个时间段“τ”内产生另外多个临时焦斑的过程。

公开(公告)号：US20060106372A1

公开(公告)日：2006-05-18

申请号：US10987542

申请日：2004-11-12

申请人： Tobias Kuhn ,  Frieder Loesel

发明人： Tobias Kuhn ,  Frieder Loesel

IPC分类号： A61F9/008 ,  A61B18/18

CPC分类号： A61F9/008 ,  A61F9/00827 ,  A61F2009/00872 ,  A61F2009/00897

摘要： A method for photodisrupting a preselected subsurface volume of corneal tissue to alter a cornea's refractive properties is disclosed. Specifically, at least one stromal volume having a substantially conical shaped surface is photodisrupted. For this purpose, a laser device having a laser source, laser scanner and one or more optical elements is typically used. In one embodiment, a plurality of stromal volumes, with each stromal volume having a substantially conical shaped surface, is sequentially photodisrupted to form a contiguous stromal cavity. In a particular implementation, each conical shaped surface defines a cone axis that is aligned to be co-linear with a reference axis that passes through the anterior surface of the eye and may be aligned orthogonally to the anterior surface of the eye.

摘要翻译： 公开了一种用于光破坏预选的地下体积的角膜组织以改变角膜的折射性质的方法。 具体地说，具有基本圆锥形表面的至少一个基质体积被光破坏。 为此，通常使用具有激光源，激光扫描器和一个或多个光学元件的激光装置。 在一个实施方案中，具有每个基质体积具有基本上圆锥形表面的多个基质体积被顺序地光致破坏以形成连续的基质腔。 在特定实施方案中，每个圆锥形表面限定锥形轴线，该锥形轴线对齐以与穿过眼睛前表面的参考轴线共线，并且可以与眼睛的前表面正交对齐。

公开(公告)号：US20060020259A1

公开(公告)日：2006-01-26

申请号：US10895276

申请日：2004-07-20

申请人： Klaus Baumeister ,  Tobias Kuhn ,  Frieder Loesel ,  Fritz Meisel

发明人： Klaus Baumeister ,  Tobias Kuhn ,  Frieder Loesel ,  Fritz Meisel

IPC分类号： A61F9/009 ,  A61B18/20 ,  A61F9/01

CPC分类号： A61F9/009 ,  A61B2017/00969 ,  A61F9/00831 ,  A61F2009/00846 ,  A61F2009/00872

摘要： A system for performing a corneal transplantation includes a laser source for generating a laser beam and a chair for positioning a patient relative to the laser source. A stabilizing element, engageable with the laser source, is fixated on the anterior surface of the patient's cornea to hold the cornea in alignment with the laser source. The laser source is then used to remove diseased tissue from the cornea of the patient, thereby creating a corneal cavity of known dimensions. In a subsequent step, a donor graft that was previously photoaltered to have substantially the same dimensions as the corneal cavity, is transplanted into the corneal cavity.

摘要翻译： 用于进行角膜移植的系统包括用于产生激光束的激光源和用于相对于激光源定位患者的椅子。 与激光源接合的稳定元件被固定在患者角膜的前表面上，以将角膜保持与激光源对准。 然后将激光源用于从患者角膜去除病变组织，从而产生已知尺寸的角膜腔。 在随后的步骤中，先前被光学变化以具有与角膜腔基本相同的尺寸的供体移植物移植到角膜腔中。

公开(公告)号：US20070078447A1

公开(公告)日：2007-04-05

申请号：US11015338

申请日：2004-12-17

申请人： Martin Weinacht ,  Frieder Loesel ,  Tobias Kuhn

发明人： Martin Weinacht ,  Frieder Loesel ,  Tobias Kuhn

IPC分类号： A61F9/008 ,  A61B18/18

CPC分类号： A61F9/008 ,  A61F9/00836 ,  A61F9/0084 ,  A61F2009/00872

摘要： A method and device for photoablation is disclosed wherein photoablation occurs along the interface between a material having a lower energy ablation threshold and a material having a higher energy ablation threshold. The method and device utilize a laser beam having a beam energy density which is less than the higher energy ablation threshold and greater than or equal to the lower energy ablation threshold. By directing such a laser beam to the interface, the material having the lower energy threshold is photoablated while the material having the higher energy threshold is largely unaffected.

摘要翻译： 公开了一种用于光消融的方法和装置，其中光消除沿着具有较低能量消融阈值的材料和具有较高能量消融阈值的材料之间的界面发生。 该方法和装置利用具有小于较高能量消融阈值并且大于或等于较低能量消融阈值的光束能量密度的激光束。 通过将这样的激光束引导到界面，具有较低能量阈值的材料被光照化，而具有较高能量阈值的材料在很大程度上不受影响。

公开(公告)号：US20060192921A1

公开(公告)日：2006-08-31

申请号：US11066726

申请日：2005-02-25

申请人： Frieder Loesel ,  Fritz Meisel ,  Bernhard Gress ,  Tobias Kuhn

发明人： Frieder Loesel ,  Fritz Meisel ,  Bernhard Gress ,  Tobias Kuhn

IPC分类号： A61B3/00

CPC分类号： A61F9/009 ,  A61B2017/306 ,  A61F9/008

摘要： A device for establishing a desired alignment between a patient's eye and a laser system to facilitate an engagement therebetween includes a light source to illuminate the eye. A moveable platform is provided to move the patient relative to the laser system. To establish alignment between the eye and the laser system, a reference marker is based on the laser system. An image of the marker, along with reflections from the illuminated eye, is then transmitted to the system controller. There, the image and reflections are processed to determine a measured alignment that is then compared to the desired alignment. An error signal that is indicative of an alignment difference is then generated and used to incrementally move the platform, or the patient, in an appropriate direction.

摘要翻译： 用于在患者的眼睛和激光系统之间建立期望的对准以便于其间的接合的装置包括照亮眼睛的光源。 提供可移动平台以相对于激光系统移动患者。 为了建立眼睛和激光系统之间的对准，参考标记基于激光系统。 然后将标记的图像以及来自照明眼睛的反射传输到系统控制器。 在那里，处理图像和反射以确定测量的对准，然后将其与期望的对准进行比较。 然后产生指示对准差异的误差信号并用于沿适当的方向递增地移动平台或患者。

公开(公告)号：US20060095023A1

公开(公告)日：2006-05-04

申请号：US10978613

申请日：2004-11-01

申请人： Frieder Loesel ,  Tobias Kuhn

发明人： Frieder Loesel ,  Tobias Kuhn

IPC分类号： A61F9/008 ,  A61B18/18

CPC分类号： A61F9/008 ,  A61F9/00825 ,  A61F2009/00872 ,  A61F2009/00897

摘要： A system and method for performing laser induced optical breakdown (LIOB) in corneal tissue of an eye requires calculating a pattern of focal spots. LIOB is then induced at a first focal spot, and is continued at a plurality of interim focal spots within a time period τ. Each focal spot has a diameter “d1” and generates a temporal cavitation bubble of diameter “d2”. It then collapses within time “τ” to a substantially stationary diameter “d3”, with (d1≦d3≦d2). Importantly, each focal spot is located more than “d2” from every other interim focal spot within the time period of “τ”. At the time “τ”, a second focal spot in the pattern can be generated at a distance “d3” from the first focal spot. This process is then continued with another plurality of interim focal spots being generated within another time period “τ”.

摘要翻译： 用于在眼睛的角膜组织中进行激光诱导光学击穿（LIOB）的系统和方法需要计算焦点的图案。 然后在第一焦点处诱导LIOB，并且在时间段τ内的多个临时焦斑处继续。 每个焦点具有直径“d”1“并且产生直径”d 2“的时间空化气泡。 然后，它在时间“τ”内塌陷到基本上静止的直径“d”3“，其中（d 1/3）= D 3 2 ）。 重要的是，在“τ”的时间段内，每个焦斑位于比其他中间焦斑多于“d <2> 2 ”。 在“τ”时，图案中的第二焦斑可以从第一焦斑的距离“d”3“生成。 然后继续在另一个时间段“τ”内产生另外多个临时焦斑的过程。

公开(公告)号：US07892225B2

公开(公告)日：2011-02-22

申请号：US11015338

申请日：2004-12-17

申请人： Martin Weinacht ,  Frieder Loesel ,  Tobias Kuhn

发明人： Martin Weinacht ,  Frieder Loesel ,  Tobias Kuhn

IPC分类号： A61B18/18

CPC分类号： A61F9/008 ,  A61F9/00836 ,  A61F9/0084 ,  A61F2009/00872

摘要： A method and device for photoablation is disclosed wherein photoablation occurs along the interface between a material having a lower energy ablation threshold and a material having a higher energy ablation threshold. The method and device utilize a laser beam having a beam energy density which is less than the higher energy ablation threshold and greater than or equal to the lower energy ablation threshold. By directing such a laser beam to the interface, the material having the lower energy threshold is photoablated while the material having the higher energy threshold is largely unaffected.

摘要翻译： 公开了一种用于光消融的方法和装置，其中光消除沿着具有较低能量消融阈值的材料和具有较高能量消融阈值的材料之间的界面发生。 该方法和装置利用具有小于较高能量消融阈值并且大于或等于较低能量消融阈值的光束能量密度的激光束。 通过将这样的激光束引导到界面，具有较低能量阈值的材料被光照化，而具有较高能量阈值的材料在很大程度上不受影响。

公开(公告)号：US07662148B2

公开(公告)日：2010-02-16

申请号：US10987542

申请日：2004-11-12

申请人： Tobias Kuhn ,  Frieder Loesel

发明人： Tobias Kuhn ,  Frieder Loesel

IPC分类号： A61F9/008

CPC分类号： A61F9/008 ,  A61F9/00827 ,  A61F2009/00872 ,  A61F2009/00897

摘要： A method for photodisrupting a preselected subsurface volume of corneal tissue to alter a cornea's refractive properties is disclosed. Specifically, at least one stromal volume having a substantially conical shaped surface is photodisrupted. For this purpose, a laser device having a laser source, laser scanner and one or more optical elements is typically used. In one embodiment, a plurality of stromal volumes, with each stromal volume having a substantially conical shaped surface, is sequentially photodisrupted to form a contiguous stromal cavity. In a particular implementation, each conical shaped surface defines a cone axis that is aligned to be co-linear with a reference axis that passes through the anterior surface of the eye and may be aligned orthogonally to the anterior surface of the eye.

摘要翻译： 公开了一种用于光破坏预选的地下体积的角膜组织以改变角膜的折射性质的方法。 具体地说，具有基本圆锥形表面的至少一个基质体积被光破坏。 为此，通常使用具有激光源，激光扫描器和一个或多个光学元件的激光装置。 在一个实施方案中，具有每个基质体积具有基本上圆锥形表面的多个基质体积被顺序地光致破坏以形成连续的基质腔。 在特定实施方案中，每个圆锥形表面限定锥形轴线，该锥形轴线对齐以与穿过眼睛前表面的参考轴线共线，并且可以与眼睛的前表面正交对齐。

公开(公告)号：US07390089B2

公开(公告)日：2008-06-24

申请号：US11066726

申请日：2005-02-25

申请人： Frieder Loesel ,  Fritz Meisel ,  Bernhard Gress ,  Tobias Kuhn

发明人： Frieder Loesel ,  Fritz Meisel ,  Bernhard Gress ,  Tobias Kuhn

IPC分类号： A61B3/00

CPC分类号： A61F9/009 ,  A61B2017/306 ,  A61F9/008

摘要： A device for establishing a desired alignment between a patient's eye and a laser system to facilitate an engagement therebetween includes a light source to illuminate the eye. A moveable platform is provided to move the patient relative to the laser system. To establish alignment between the eye and the laser system, a reference marker is based on the laser system. An image of the marker, along with reflections from the illuminated eye, is then transmitted to the system controller. There, the image and reflections are processed to determine a measured alignment that is then compared to the desired alignment. An error signal that is indicative of an alignment difference is then generated and used to incrementally move the platform, or the patient, in an appropriate direction.

摘要翻译： 用于在患者的眼睛和激光系统之间建立期望的对准以便于其间的接合的装置包括照亮眼睛的光源。 提供可移动平台以相对于激光系统移动患者。 为了建立眼睛和激光系统之间的对准，参考标记基于激光系统。 然后将标记的图像以及来自照明眼睛的反射传输到系统控制器。 在那里，处理图像和反射以确定测量的对准，然后将其与期望的对准进行比较。 然后产生指示对准差异的误差信号并用于沿适当的方向递增地移动平台或患者。

公开(公告)号：US20070027438A1

公开(公告)日：2007-02-01

申请号：US11189426

申请日：2005-07-26

申请人： Frieder Loesel ,  Tobias Kuhn

发明人： Frieder Loesel ,  Tobias Kuhn

IPC分类号： A61B18/18

CPC分类号： A61F9/008 ,  A61B34/10 ,  A61F9/00829 ,  A61F2009/00853 ,  A61F2009/00872 ,  A61F2009/0088

摘要： A system and method for dissecting a transparent material utilizes pre-dissection diagnostic information about the transparent material. Specifically, in the system and method, a prototypic dissection path is planned to achieve a desired result. Then, the topology of the transparent material is defined and analyzed to calculate a predicted result of a dissection along the prototypic dissection path. After comparing the desired result and the predicted result, a refined dissection path is established in which any difference between the predicted result of a dissection along the refined dissection path and the desired result is minimized. As a result, dissection of the transparent material along the refined dissection path achieves the desired result.

摘要翻译： 用于解剖透明材料的系统和方法利用关于透明材料的预解剖诊断信息。 具体来说，在该系统和方法中，计划将原型解剖路径实现期望的结果。 然后，定义和分析透明材料的拓扑结构，以计算沿原型夹层路径的夹层的预测结果。 在比较所需结果和预测结果之后，建立精确的解剖路径，其中沿着精细解剖路径的解剖的预测结果与期望结果之间的任何差异被最小化。 结果，沿着精细解剖路径的透明材料的解剖实现了期望的结果。