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公开(公告)号:US20250042892A1
公开(公告)日:2025-02-06
申请号:US18807978
申请日:2024-08-18
Applicant: Fudan University
Inventor: Ge MENG , Weijuan GE , Jing TONG , Yanan CHENG , Huiling CAO
IPC: C07D417/12 , A61K31/427
Abstract: A series of 2-(5-substituted-indolone-3-yl-hydrozono)-3-substituted-arylidene-1,3-thiazolidinone derivatives represented by where R1 is Cl, F, Br or CH3, and R2 is 4-F, 3-Cl, 3-CF3 or 4-C(CH3)3. A pharmaceutical composition including such 2-(5-substituted-indolone-3-yl-hydrozono)-3-substituted-arylidene-1,3-thiazolidinone derivative, or a pharmaceutically-acceptable salt thereof is provided. A preparation method of such derivative and an application of such derivative as a lead compound in the preparation of PARP14 inhibitors are further provided.