公开(公告)号：US20230183196A1

公开(公告)日：2023-06-15

申请号：US18166478

申请日：2023-02-09

Applicant: Fudan University

Inventor： Fener CHEN ,  Meifen JIANG ,  Minjie LIU ,  Yingqi XIA ,  Weijian LI

IPC: C07D279/06

CPC classification number: C07D279/06

Abstract: to enter a second continuous filtration and reaction device for filtration to collect a filter cake; and subjecting the filter cake to reaction with organic hydrochloric acid solution followed by filtration and drying to obtain vitamin B1.

公开(公告)号：US20230127147A1

公开(公告)日：2023-04-27

申请号：US18068151

申请日：2022-12-19

Applicant: Fudan University

Inventor： Fener CHEN ,  Minjie LIU ,  Meifen JIANG ,  Yingqi XIA ,  Huashan HUANG

IPC: C07C315/02 ,  C07C315/06

Abstract: A continuous-flow preparation method of diol sulfone using a two-stage micro-reaction system. The system includes a first micro-mixer, a first micro-channel reactor, a second micro-mixer, and a second micro-channel reactor communicated in sequence. The method includes: feeding hydrogen peroxide, a catalyst and a diol thioether solution simultaneously to the first micro-mixer followed by mixing; feeding the reaction mixture to the first micro-channel reactor for continuous oxidation; and feeding the reaction mixture and water simultaneously to the second micro-mixer and the second micro-channel reactor for continuous quenching and crystallization to obtain diol sulfone.