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公开(公告)号：US20230127345A1
公开(公告)日：2023-04-27
申请号：US18052814
申请日：2022-11-04
发明人： Sharon Shechter , Eliezer Zomer , Peter G. Traber , Raphael Nir , Joseph M. Johnson , Ryan George
IPC分类号： C07H19/056 , A61P1/16 , A61P9/00 , A61P13/12 , A61P11/00 , A61K31/7056 , A61K45/06
摘要： Aspects of the invention relate to novel synthetic compounds having a binding affinity with galectin proteins.
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公开(公告)号：US11576924B2
公开(公告)日：2023-02-14
申请号：US16611609
申请日：2018-05-11
发明人： Eliezer Zomer , Peter G. Traber , Raphael Nir , Sharon Shechter , Joseph M. Johnson , Ryan George
IPC分类号： A61K31/7056 , A61P1/16 , A61P9/00 , A61P13/12 , A61K45/06 , C07H17/00 , C07H17/02 , C07H99/00
摘要： Aspects of the invention relate to novel synthetic compounds having binding affinity with galectin proteins.
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公开(公告)号：US20200147088A1
公开(公告)日：2020-05-14
申请号：US16629373
申请日：2018-08-03
发明人： Raphael Nir , Eliezer Zomer , Peter G. Traber , Joseph M. Johnson , Ryan George , Sharon Shechter
IPC分类号： A61K31/519 , A61K45/06 , C07D487/04 , A61P3/10
摘要： Aspects of the invention relate to compounds, pharmaceutical compositions, methods for the manufacturing of compounds and methods for treatment of various disorders mediated at least in part by one or more galectins.
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公开(公告)号：US11583530B2
公开(公告)日：2023-02-21
申请号：US16629373
申请日：2018-08-03
发明人： Raphael Nir , Eliezer Zomer , Peter G. Traber , Joseph M. Johnson , Ryan George , Sharon Shechter
IPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , A61P3/10
摘要： Aspects of the invention relate to compounds, pharmaceutical compositions, methods for the manufacturing of compounds and methods for treatment of various disorders mediated at least in part by one or more galectins.
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公开(公告)号：US20230132265A1
公开(公告)日：2023-04-27
申请号：US17835363
申请日：2022-06-08
发明人： Eliezer Zomer , Peter G. Traber , Raphael Nir , Sharon Shechter , Joseph M. Johnson , Ryan George
IPC分类号： A61K31/7056 , A61P1/16 , A61P9/00 , A61P13/12 , A61K45/06 , C07H17/00 , C07H17/02 , C07H99/00
摘要： Aspects of the invention relate to novel synthetic compounds having binding affinity with galectin proteins.
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公开(公告)号：US20200155586A1
公开(公告)日：2020-05-21
申请号：US16611609
申请日：2018-05-11
发明人： Eliezer Zomer , Peter G. Traber , Raphael Nir , Sharon Shechter , Joseph M. Johnson , Ryan George
IPC分类号： A61K31/7056 , A61K45/06 , C07H17/02 , C07H99/00 , C07H17/00 , A61P1/16 , A61P13/12 , A61P9/00
摘要： Aspects of the invention relate to novel synthetic compounds having binding affinity with galectin proteins.
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7.发明申请公开(公告)号：US20200061095A1
公开(公告)日：2020-02-27
申请号：US16611620
申请日：2018-05-11
发明人： Peter G. Traber , Eliezer Zomer , Deirdre Slate , Joseph M. Johnson , Ryan George , Sharon Shechter , Raphael Nir
IPC分类号： A61K31/7056 , A61K31/4439 , A61P3/10 , A61K45/06
摘要： Aspects of the invention relate to novel synthetic compounds for treatment of metabolic diseases partially associated with systemic insulin resistance caused by Galectin proteins binding and inhibiting insulin and TGFb1 receptors causing physiological disturbances in the insulin pathways.
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