公开(公告)号：US09834504B2

公开(公告)日：2017-12-05

申请号：US15100718

申请日：2014-12-08

申请人： GE Healthcare AS

发明人： Torfinn Haaland ,  Arne Askildsen ,  Rita Heskestad Kalleberg ,  Sumihar Silalahi ,  Alf Martin Farbrot ,  Inger Dagny Saanum

IPC分类号： C07C231/24 ,  C07C231/02 ,  C07C237/46

CPC分类号： C07C231/24 ,  C07C231/02 ,  C07C237/46

摘要： Alternative continuous downstream processes for the production of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”) are described. Compound A is a key intermediate in the production of iodixanol and iohexol, which are two of the biggest commercially available non-ionic x-ray contrast media agents.

公开(公告)号：US09695113B2

公开(公告)日：2017-07-04

申请号：US15100818

申请日：2014-12-08

申请人： GE Healthcare AS

发明人： Torfinn Haaland ,  Arne Askildsen ,  Rita Heskestad Kalleberg ,  Sumihar Silalahi ,  Alf Martin Farbrot ,  Inger Dagny Saanum

IPC分类号： C07C231/24 ,  C07C231/02 ,  C07C237/46

CPC分类号： C07C231/24 ,  C07C231/02 ,  C07C237/46

摘要： Alternative continuous downstream processes for the production of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”) are described. Compound A is a key intermediate in the production of iodixanol and iohexol, which are two of the biggest commercially available non-ionic x-ray contrast media agents.

公开(公告)号：US10011560B2

公开(公告)日：2018-07-03

申请号：US15603681

申请日：2017-05-24

申请人： GE HEALTHCARE AS

发明人： Torfinn Haaland ,  Arne Askildsen ,  Rita Heskestad Kalleberg ,  Sumihar Silalahi ,  Alf Martin Farbrot ,  Inger Dagny Saanum

IPC分类号： C07C231/24 ,  C07C231/02

CPC分类号： C07C231/24 ,  C07C231/02 ,  C07C237/46

摘要： Alternative continuous downstream processes for the production of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”) are described. Compound A is a key intermediate in the production of iodixanol and iohexol, which are two of the biggest commercially available non-ionic x-ray contrast media agents.

公开(公告)号：US20160289174A1

公开(公告)日：2016-10-06

申请号：US15100818

申请日：2014-12-08

申请人： GE HEALTHCARE AS

发明人： Torfinn Haaland ,  Arne ASKILDSEN ,  Rita Heskestad Kalleberg ,  Sumihar Silalahi ,  Alf Martin Farbrot ,  Inger Dagny Saanum

IPC分类号： C07C231/24 ,  C07C231/02

CPC分类号： C07C231/24 ,  C07C231/02 ,  C07C237/46

摘要： Alternative continuous downstream processes for the production of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”) are described. Compound A is a key intermediate in the production of iodixanol and iohexol, which are two of the biggest commercially available non-ionic x-ray contrast media agents.

摘要翻译： 描述了用于生产5-乙酰氨基-N，N'-双（2,3-二羟丙基）-2,4,6-三碘间苯二酰胺（“化合物A”）的替代连续下游方法。 化合物A是生产碘克沙醇和碘海醇的关键中间体，它是两种最大的市售非离子型X射线造影剂。