公开(公告)号：US11576979B2

公开(公告)日：2023-02-14

申请号：US16689286

申请日：2019-11-20

Applicant: GENENTECH, INC.

Inventor： Peter Dragovich ,  Zhonghua Pei ,  Thomas Pillow ,  Jack Sadowsky ,  Vishal Verma ,  Donglu Zhang

IPC: A61K47/68 ,  A61P35/00 ,  A61K31/5517

Abstract: The invention relates generally to pyrrolobenzodiazepine monomer and dimer prodrugs having a glutathione-activated disulfide prodrug moiety, a DT-diaphorase-activated quinone prodrug moiety or a reactive oxygen species-activated aryl boronic acid or aryl boronic ester prodrug moiety. The invention further relates to pyrrolobenzodiazepine prodrug dimer-antibody conjugates.

公开(公告)号：US10532108B2

公开(公告)日：2020-01-14

申请号：US16271549

申请日：2019-02-08

Applicant: GENENTECH, INC.

Inventor： Peter Dragovich ,  Zhonghua Pei ,  Thomas Pillow ,  Jack Sadowsky ,  Vishal Verma ,  Donglu Zhang

IPC: A61K47/68 ,  A61P35/00 ,  A61K31/5517

Abstract: The invention relates generally to pyrrolobenzodiazepine monomer and dimer prodrugs having a glutathione-activated disulfide prodrug moiety, a DT-diaphorase-activated quinone prodrug moiety or a reactive oxygen species-activated aryl boronic acid or aryl boronic ester prodrug moiety. The invention further relates to pyrrolobenzodiazepine prodrug dimer-antibody conjugates.