公开(公告)号：US20230385475A1

公开(公告)日：2023-11-30

申请号：US18447986

申请日：2023-08-10

Applicant: GENENTECH, INC.

Inventor： Jessica Yang LYALL ,  Connor James THOMPSON ,  Sean Mackenzie BURGESS

IPC: G06F30/17 ,  G06F30/20

CPC classification number: G06F30/17 ,  G06F30/20

Abstract: A method, system, and non-transitory computer readable medium for estimating mechanistic chromatography model uncertainty. A mechanistic model of chromatography that comprises a plurality of parameters is received. For each of the plurality of parameters, a corresponding region of values is identified based on a relationship between values for the plurality of parameters. Each parameter of the plurality of parameters is sampled within the corresponding region of values for each parameter to form a plurality of simulation sets. An uncertainty for the mechanistic model is quantified using the plurality of simulation sets.