公开(公告)号：US10564165B2

公开(公告)日：2020-02-18

申请号：US14850864

申请日：2015-09-10

Applicant: GENENTECH, INC.

Inventor： Lelia Delamarre ,  Patrick Lupardus ,  Ira Mellman ,  Mahesh Yadav ,  Suchit Jhunjhunwala ,  Jennie Lill

IPC: G01N33/68 ,  C12Q1/6886 ,  A61K39/00 ,  G01N33/569

Abstract: The present disclosure provides methods of identifying a disease-specific immunogenic peptide through a series of selection steps. Immunogenic epitopes identified by methods of the present disclosure are applicable for use in peptide-based immunotherapy, preferably cancer therapy. Furthermore, the methods of the present disclosure may be performed in a high-throughput manner and serve as a means of personalized vaccine development and therapy. Also provided are compositions of immunogenic peptides as well as methods of treatment comprising said compositions.