公开(公告)号：US20180201692A1

公开(公告)日：2018-07-19

申请号：US15728816

申请日：2017-10-10

Applicant: GENENTECH, INC.

Inventor： Henry B. Lowman ,  Resi B. Gerstner ,  Paul J. Carter

IPC: C07K16/32 ,  A61J1/18 ,  C07K16/30 ,  A61J1/00

CPC classification number: C07K16/32 ,  A61J1/00 ,  A61J1/18 ,  A61J2205/30 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/92

Abstract: The present invention concerns novel antibody variants, particularly anti-HER2 antibody variants having substitutions at positions within the variable domains of the heavy and light chains

公开(公告)号：US20170166656A1

公开(公告)日：2017-06-15

申请号：US15444037

申请日：2017-02-27

Applicant: GENENTECH, INC.

Inventor： Henry B. Lowman ,  Resi B. Gerstner ,  Paul J. Carter

IPC: C07K16/32 ,  A61J1/18 ,  C07K16/30

CPC classification number: C07K16/32 ,  A61J1/00 ,  A61J1/18 ,  A61J2205/30 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/92

Abstract: The present invention concerns novel antibody variants, particularly anti-HER2 antibody variants having substitutions at positions within the variable domains of the heavy and light chains