公开(公告)号：US20190185935A1

公开(公告)日：2019-06-20

申请号：US16105952

申请日：2018-08-20

Applicant: GENENTECH, INC.

Inventor： Brian YASPAN ,  Robert Royal GRAHAM ,  Amy DRESSEN ,  Zhengrong LI ,  Erich STRAUSS ,  Teodorica BUGAWAN

IPC: C12Q1/6883 ,  C07K16/40

CPC classification number: C12Q1/6883 ,  A61K2039/505 ,  C07K16/40 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156

Abstract: The invention provides methods and compositions for treating various degenerative diseases (e.g., AMD) with a factor D inhibitor (e.g., anti-factor D antibody or antigen-binding fragment thereof). Also provided are methods of selecting or identifying patients for treatment with a factor D inhibitor. Methods include the use of prognostic and/or predictive biomarkers.