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公开(公告)号：US10894097B2
公开(公告)日：2021-01-19
申请号：US16145115
申请日：2018-09-27
Applicant: GENERAL ELECTRIC COMPANY , AFFIBODY AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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公开(公告)号：US20240139352A1
公开(公告)日：2024-05-02
申请号：US18119070
申请日：2023-03-08
Applicant: General Electric Company , Affibody AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
CPC classification number: A61K51/088 , C07K14/71
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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公开(公告)号：US20210170057A1
公开(公告)日：2021-06-10
申请号：US17117697
申请日：2020-12-10
Applicant: General Electric Company , Affibody AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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公开(公告)号：US20190262481A1
公开(公告)日：2019-08-29
申请号：US16145115
申请日：2018-09-27
Applicant: GENERAL ELECTRIC COMPANY , AFFIBODY AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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Patent Agency Ranking
公开(公告)号：US10159760B2
公开(公告)日：2018-12-25
申请号：US15083424
申请日：2016-03-29
Applicant: General Electric Company , AFFIBODY AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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公开(公告)号：US09040019B2
公开(公告)日：2015-05-26
申请号：US13689819
申请日：2012-11-30
Applicant: General Electric Company
Inventor： Tiberiu Mircea Siclovan , Cristina Abucay Tan Hehir , Rong Zhang , Victoria Eugenia Cotero , Anshika Bajaj
CPC classification number: A61K49/0021 , A61K49/0002 , G01N33/6893 , G01N2800/285
Abstract: A method and a kit for detecting myelin basic protein are provided. The method comprises administering an agent, which binds to myelin basic protein (MBP), to a subject at risk of or diagnosed with a myelin-associated neuropathy, and determining myelination by detecting the agent resided in the subject. The amount of the agent present in the subject is indicative of a myelin-associated neuropathy. A method of quantifying an amount of MBP present in a tissue sample is also provided, wherein the method comprises contacting the tissue sample with the same agent, detecting the agent present in the tissue sample; and quantifying an amount of the agent present in the tissue sample.
Abstract translation: 提供了一种用于检测髓磷脂碱性蛋白的方法和试剂盒。 该方法包括将与髓磷脂碱性蛋白（MBP）结合的药剂施用于患有髓鞘相关性神经病的风险的受试者，并通过检测存在于受试者中的药物来确定髓鞘形成。 存在于受试者中的药剂的量指示髓鞘相关神经病变。 还提供了定量存在于组织样品中的MBP量的方法，其中所述方法包括使组织样品与相同的试剂接触，检测组织样品中存在的试剂; 并定量存在于组织样品中的试剂的量。
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公开(公告)号：US20140154178A1
公开(公告)日：2014-06-05
申请号：US13689819
申请日：2012-11-30
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Tiberiu Mircea Siclovan , Cristina Abucay Tan Hehir , Rong Zhang , Victoria Eugenia Cotero , Anshika Bajaj
CPC classification number: A61K49/0021 , A61K49/0002 , G01N33/6893 , G01N2800/285
Abstract: A method and a kit for detecting myelin basic protein are provided. The method comprises administering an agent, which binds to myelin basic protein (MBP), to a subject at risk of or diagnosed with a myelin-associated neuropathy, and determining myelination by detecting the agent resided in the subject. The amount of the agent present in the subject is indicative of a myelin-associated neuropathy. A method of quantifying an amount of MBP present in a tissue sample is also provided, wherein the method comprises contacting the tissue sample with the same agent, detecting the agent present in the tissue sample; and quantifying an amount of the agent present in the tissue sample.
Abstract translation: 提供了一种用于检测髓磷脂碱性蛋白的方法和试剂盒。 该方法包括将与髓磷脂碱性蛋白（MBP）结合的药剂施用于患有髓鞘相关性神经病的风险的受试者，并通过检测存在于受试者中的药物来确定髓鞘形成。 存在于受试者中的药剂的量指示髓鞘相关神经病变。 还提供了定量存在于组织样品中的MBP量的方法，其中所述方法包括使组织样品与相同的试剂接触，检测组织样品中存在的试剂; 并定量存在于组织样品中的试剂的量。
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公开(公告)号：US11633507B2
公开(公告)日：2023-04-25
申请号：US17117697
申请日：2020-12-10
Applicant: General Electric Company , Affibody AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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公开(公告)号：US20160199521A1
公开(公告)日：2016-07-14
申请号：US15083424
申请日：2016-03-29
Applicant: General Electric Company , AFFIBODY AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
IPC: A61K51/08
CPC classification number: A61K51/088 , C07K14/71
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
Abstract translation: 包含与放射性核素和螯合剂缀合的分离的多肽的成像剂; 其中所述分离的多肽特异性结合HER2或其变体; 以及制备和使用这些成像剂的方法。
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