公开(公告)号：US20250034643A1

公开(公告)日：2025-01-30

申请号：US18717030

申请日：2022-12-13

Applicant: GENESPECTOR S.R.O.

Inventor： Ilona HROMADNIKOVA

IPC: C12Q1/6883

Abstract: Method of prediction of pregnancy complications, such as preeclampsia, fetal growth restriction, gestational hypertension, small for gestational age fetus, preterm birth, and also detection of chronic hypertension. Pregnant women are screened to determine the expression profile of one or more miRNAs in whole peripheral venous blood collected in the period of 10th-13th gestational week, whereas said one or more miRNAs are selected from the group miR-1-3p, miR-16-5p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-24-3p, miR-26a-5p, miR-92a-3p, miR-100-5p, miR-103a-3p, miR-126-3p, miR-130b-3p, miR-133a-3p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-155-5p, miR-181a-5p, miR-195-5p, miR-210-3p, miR-221-3p, miR-342-3p, miR-499a-5p, and miR-574-3p.